Results 61 to 70 of about 842,482 (293)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Jurnal Komputer Terapan, 2020 Pemeriksaan USG merupakan salah satu cara yang paling sering digunakan untuk skrining kanker payudara namun hasilnya sangat subjektif. Oleh karena itu, diperlukan suatu sistem yang mampu mendiagnosa keganasan kanker payudara dari berbagai parameter ...
Tianur Tianur, Edilla Edilla
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Predicted Virtual Soft Shadow Maps with High Quality Filtering [PDF]
Computer Graphics Forum, 2011 AbstractIn this paper we present a novel image based algorithm to render visually plausible anti‐aliased soft shadows in a robust and efficient manner. To achieve both high visual quality and high performance, it employs an accurate shadow map filtering method which guarantees smooth penumbrae and high quality anisotropic anti‐aliasing of the sharp ...
Li, Shen +3 more
openaire +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
A Generalised Linear and Nonlinear Spline filter [PDF]
In this paper, a generalised spline filter, that has a unified description for both the linear spline filter and the nonlinear robust spline filter, is proposed.
Zeng, Wenhan +2 more
core +4 more sources
Fusion of Multi-Baseline and Multi-Orbit InSAR DEMs with Terrain Feature-Guided Filter
Remote Sensing, 2018 Interferometric synthetic aperture radar (InSAR) is an effective technology for generating high-precision digital elevation models (DEMs). However, the vertical accuracy of InSAR DEMs is limited by the contradiction between height measurement sensitivity
Yuting Dong +4 more
doaj +1 more source
Tracking a single pigeon using a shadowing filter algorithm
Ecology and Evolution, 2017 AbstractMiniature GPS devices now allow for measurement of the movement of animals in real time and provide high‐ quality and high‐resolution data. While these new data sets are a great improvement, one still encounters some measurement errors as well as device failures.
Ayham Zaitouny +2 more
openaire +3 more sources
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
This paper investigates the border between formal employment, shadow employment, and unemployment in an equilibrium model of the labor market with market frictions.
Tito Boeri, Pietro Garibaldi
core