Results 121 to 130 of about 101,051 (295)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Colored Shadows

, 1889
COLORED SHADOWS Colored Shadows (2) (-
Delabarre, Edmund B.
core   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Retrieving optical depth from shadows in orbiter images of Mars

, 2011
International audience► The optical depth of the Martian atmosphere determines the brightness of shadows ► We estimate the optical depth from the brightness of shadows in orbiter images ► It is best to use images taken in colors between yellow and red ...
Markiewicz, W.J., W.A. Delamere, Thomas, N., Garcia-Comas, M., Hoekzema, N. M., O.J. Stenzel, Delamere, W.A., Keller, H.U., Petrova, E. V., M. Garcia-Comas, E.V. Petrova, Hoekzema, N.M., Keller, H. U., Keller, H., Stenzel, O.J., Hoekzema, N., Stenzel, O. J., N.M. Hoekzema, Stenzel, O., Petrova, E., H.U. Keller, W.J. Markiewicz, Delamere, W. A., Petrova, E.V., K. Gwinner, Gwinner, K., N. Thomas, Delamere, W., Markiewicz, W. J., Markiewicz, W.   +29 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mitigating terrain shadows in very high-resolution satellite imagery for accurate evergreen conifer detection using bi-temporal image fusion

International Journal of Applied Earth Observations and Geoinformation
Very high-resolution (VHR) optical satellite imagery offers significant potential for detailed land cover mapping. However, terrain shadows, which appear dark and lack texture and detail, are especially acute at low solar elevations. These shadows hinder
Xiao Zhu, Tiejun Wang, Andrew K. Skidmore, Stephen J. Lee, Isla Duporge   +4 more
doaj   +1 more source

Technical shadows [PDF]

, 2018
Title: Technical shadows Author: Jana Vlčková Department: Departement of Mathematics Education Supervisor: RNDr. Jana Hromadová, Ph.D., Departement of Mathematics Education Abstract: This bachelor's thesis concerns with the topic of technical shadows ...
Vlčková, Jana
core  

Stylized shadows

, 2007
Figure 1: Traditional computer graphics algorithms produce “accurate ” shadows (left). Artists often deliberately render abstract shadows, such as the shadow with reduced contour detail in this painting by Vanderlyn, 1818 (middle).
Christopher Decoro, Forrester Cole, Szymon Rusinkiewicz, Adam Finkelstein   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source