Results 131 to 140 of about 78,110 (303)
Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons
Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao +14 morewiley +1 more sourceNanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa +13 morewiley +1 more sourceRapidly pulsed, high intensity, incoherent light source [PDF]
, 1974 A rapid pulsing, high intensity, incoherent light is produced by selectively energizing a plurality of discharge lamps with a triggering circuit. Each lamp is connected to a capacitor, and a power supply is electrically connected to all but one of the ...Brandhorst, H. W., Jr., Evans, J. C., Jr. +1 morecore +1 more sourceNatural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean
Advanced Science, EarlyView.This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang +11 morewiley +1 more sourceKinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair
Advanced Science, EarlyView.This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel +9 morewiley +1 more sourceJUNO Conceptual Design Report [PDF]
, 2015 The Jiangmen Underground Neutrino Observatory (JUNO) is proposed to determine
the neutrino mass hierarchy using an underground liquid scintillator detector.
It is located 53 km away from both Yangjiang and Taishan Nuclear Power Plants
in Guangdong, China.Adam, T., An, F., An, G., An, Q., Anfimov, N., Antonelli, V., Avanzini, M. Buizza, Baccolo, G., Baldoncini, M., Baussan, E., Bellato, M., Bezrukov, L., Bick, D., Blyth, S., Boarin, S., Brigatti, A., Brugière, T., Brugnera, R., Busto, J., Cabrera, A., Cai, H., Cai, X., Cammi, A., Cao, D., Cao, G., Cao, J., Chang, J., Chang, Y., Chen, M., Chen, P., Chen, Q., Chen, S., Chen, S., Chen, S., Chen, X., Chen, Y., Cheng, Y., Chiesa, D., Chukanov, A., Clemenza, M., Clerbaux, B., D'Angelo, D., de Kerret, H., Deng, Z., Deng, Z., Ding, X., Ding, Y., Djurcic, Z., Dmitrievsky, S., Dolgareva, M., Dornic, D., Doroshkevich, E., Dracos, M., Drapier, O., Dusini, S., Díaz, M. A., Enqvist, T., Fan, D., Fang, C., Fang, J., Fang, X., Favart, L., Fedoseev, D., Fiorentini, G., Ford, R., Formozov, A., Gaigher, R., Gan, H., Garfagnini, A., Gaudiot, G., Genster, C., Giammarchi, M., Giuliani, F., Gonchar, M., Gong, G., Gong, H., Gonin, M., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, V., Gu, M., Guan, M., Guarino, V., Guo, W., Guo, X., Guo, Y., Göger-Neff, M., Hackspacher, P., Hagner, C., Han, R., Han, Z., Hao, J., He, M., Hellgartner, D., Heng, Y., Hong, D., Hou, S., Hsiung, Y., Hu, B., Hu, J., Hu, S., Hu, T., Hu, W., Huang, H., Huang, X., Huang, X., Huo, L., Huo, W., Ioannisian, A., Ioannisyan, D., Jeitler, M., Jen, K., Jetter, S., Ji, X., Ji, X., Jian, S., Jiang, D., Jiang, X., Jollet, C., Kaiser, M., Kan, B., Kang, L., Karagounis, M., Kazarian, N., Kettell, S., Korablev, D., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kuusiniemi, P., Lachenmaier, T., Lei, L., Lei, R., Lei, X., Leitner, R., Lenz, F., Li, C., Li, F., Li, F., Li, J., Li, N., Li, S., Li, T., Li, W., Li, W., Li, X., Li, X., Li, X., Li, X., Li, Y., Li, Y., Li, Z., Liang, H., Liang, H., Liang, J., Licciardi, M., Lin, G., Lin, S., Lin, T., Lin, Y., Lippi, I., Liu, G., Liu, H., Liu, H., Liu, J., Liu, J., Liu, J., Liu, J., Liu, Q., Liu, Q., Liu, S., Liu, S., Liu, Y., Lombardi, P., Long, Y., Lorenz, S., Lu, C., Lu, F., Lu, H., Lu, J., Lu, J., Lu, J., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luo, F., Luo, S., Lv, Z., Lyashuk, V., Ma, Q., Ma, S., Ma, X., Ma, X., Malyshkin, Y., Mantovani, F., Mao, Y., Mari, S., Mayilyan, D., McDonough, W., Meng, G., Meregaglia, A., Meroni, E., Mezzetto, M., Min, J., Miramonti, L., Montuschi, M., Morozov, N., Mueller, T., Muralidharan, P., Nastasi, M., Naumov, D., Naumova, E., Nemchenok, I., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Ortica, F., Pan, H., Paoloni, A., Parkalian, N., Parmeggiano, S., Pec, V., Pelliccia, N., Peng, H., Poussot, P., Pozzi, S., Previtali, E., Prummer, S., Qi, F., Qi, M., Qian, S., Qian, X., Qiao, H., Qin, Z., Ranucci, G., Re, A., Ren, B., Ren, J., Rezinko, T., Ricci, B., Robens, M., Romani, A., Roskovec, B., Ruan, X., Ruan, X., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sawatzki, J., Schuler, J., Selyunin, A., Shi, G., Shi, J., Shi, Y., Sinev, V., Sirignano, C., Sisti, M., Smirnov, O., Soiron, M., Stahl, A., Stanco, L., Steinmann, J., Strati, V., Sun, G., Sun, X., Sun, Y., Sun, Y., Taichenachev, D., Tang, J., Tietzsch, A., Tkachev, I., Trzaska, W. H., Tung, Y., van Waasen, S., Volpe, C., Vorobel, V., Votano, L., Wang, C., Wang, C., Wang, C., Wang, G., Wang, H., Wang, M., Wang, R., Wang, S., Wang, W., Wang, W., Wang, Y., Wang, Y., Wang, Y., Wang, Y., Wang, Z., Wang, Z., Wang, Z., Wang, Z., Wang, Z., Wei, W., Wei, Y., Weifels, M., Wen, L., Wen, Y., Wiebusch, C., Wipperfurth, S., Wong, S. C., Wonsak, B., Wu, C., Wu, Q., Wu, Z., Wurm, M., Wurtz, J., Xi, Y., Xia, D., Xia, J., Xiao, M., Xie, Y., Xu, J., Xu, J., Xu, L., Xu, Y., Yan, B., Yan, X., Yang, C., Yang, C., Yang, H., Yang, L., Yang, M., Yang, Y., Yang, Y., Yang, Y., Yanovich, E., Yao, Y., Ye, M., Ye, X., Yegin, U., Yermia, F., You, Z., Yu, B., Yu, C., Yu, C., Yu, G., Yu, Z., Yuan, Y., Yuan, Z., Zanetti, M., Zeng, P., Zeng, S., Zeng, T., Zhan, L., Zhang, C., Zhang, F., Zhang, G., Zhang, H., Zhang, J., Zhang, J., Zhang, J., Zhang, K., Zhang, P., Zhang, Q., Zhang, T., Zhang, X., Zhang, X., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Z., Zhang, Z., Zhao, J., Zhao, M., Zhao, T., Zhao, Y., Zheng, H., Zheng, M., Zheng, X., Zheng, Y., Zhong, W., Zhou, G., Zhou, J., Zhou, L., Zhou, N., Zhou, R., Zhou, S., Zhou, W., Zhou, X., Zhou, Y., Zhu, H., Zhu, K., Zhuang, H., Zong, L., Zou, J. +396 morecore +1 more sourcem5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4
Advanced Science, EarlyView.In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji +16 morewiley +1 more source