Results 121 to 130 of about 17,254 (263)

Structure‐Guided Engineering of Oleate Hydratase for the Synthesis of Small Chiral Alcohols without Decoy Molecule

Advanced Synthesis &Catalysis, EarlyView.
Abstract Small and chiral secondary alcohols are sought‐after compounds that are frequently used in the synthesis of biologically active compounds. However, their stereochemically correct synthesis remains a challenge for the chemical industry. Synthetic routes are restrained by multiple steps and thus low atom efficiency.
Natalie Härterich, Andreas Schneider, Philip Horz, Nicolas D. Travnicek, Bernhard Hauer   +4 more
wiley   +1 more source

Constant enzymatic in situ production of H₂O₂ for an Unspecific Peroxygenase by an L‐amino acid oxidase

Advanced Synthesis &Catalysis, Accepted Article.
Unspecific Peroxygenases have been the subject of a lot of research in the recent past as they offer opportunities for green hydroxylation reactions using hydrogen peroxide (H₂O₂) as donor. A striking problem of UPOs is their low stability against their own co‐substrate H₂O₂.
Simon Last, Tobias Heinks, Niklas Dietz, Simon Koopmeiners, Gabriele Fischer von Mollard, Martin Weissenborn, Jan von Langermann   +6 more
wiley   +1 more source

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Advanced Synthesis &Catalysis, EarlyView.
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki   +5 more
wiley   +1 more source

Functional Molecule‐Integrated Nano‐Interfaces for Detection of Extracellular Vesicles

Advanced Sensor Research, EarlyView.
Functional molecule‐integrated nano‐interfaces for detection of extracellular vesicles prepared via template polymerization using multifunctional polymer–silica nanoparticle complex as a template followed by post‐functionalization modification are demonstrated.
Hirobumi Sunayama, Yuya Matsui, Toshifumi Takeuchi   +2 more
wiley   +1 more source

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

Advanced Science, EarlyView.
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf, Ben S. Ou, Ye Eun Song, Joshua J. Carter, Jerry Yan, Carolyn K. Jons, Christopher O. Barnes, Eric A. Appel   +7 more
wiley   +1 more source

Analysis of the influence of flame sterilization included in sampling operations on shake-flask cultures of microorganisms. [PDF]

Sci Rep, 2020
Takahashi M, Honzawa T, Tominaga R, Aoyagi H.   +3 more
europepmc   +1 more source

Optimization of process variables for acetoin production in a bioreactor using Taguchi orthogonal array design

Heliyon, 2020
Microbial production of acetoin is eco-friendly and inexpensive when compared with its synthetic methods of production. In the present findings, bioproduction of acetoin in a typical bioreactor was discussed with a view to ascertain the seemingly ...
Abiola Ezekiel Taiwo, Tafirenyika Nyamayaro Madzimbamuto, Tunde Victor Ojumu   +2 more
doaj  

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Kinetics of Avermectin B1b Production by Streptomyces avermitilis 41445 UV 45(m)3 in Shake Flask Culture. [PDF]

Iran J Biotechnol, 2020
Siddique S, Ashraf Qureshi F.
europepmc   +1 more source

Developing Quorum Sensing‐Based Collaborative Dynamic Control System in Halomonas TD01

Advanced Science, EarlyView.
A standardized and streamlined inducer‐free quorum sensing (QS)‐based collaborative dynamic control pattern is developed for sufficient gene expression control in Halomonas TD by mixing two engineered cells, cells A and B. Proof‐of‐concept studies are designed to test the dynamic control performance in mixed cultures in fed‐batch conditions.
Yi‐Na Lin, Yu‐Xi Li, Ye Zheng, Yi‐Hao Deng, Kai‐Xuan Liu, Yue Gan, Hao Li, Jun Wang, Jia‐Wen Peng, Rui‐Zhe Deng, Huai‐Ming Wang, Hui Wang, Jian‐Wen Ye   +12 more
wiley   +1 more source