Results 31 to 40 of about 34,893 (269)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Motion analysis of furniture under seismic excitation using the finite element method

Japan Architectural Review, 2018
Improperly secured furniture, especially on the upper floors of high‐rise buildings under long‐period ground motion, can prove dangerous to human life. Fallen items of furniture such as chairs and desks could become fatal obstacles that prevent efficient
Daigoro Isobe, Takuzo Yamashita, Hiroyuki Tagawa, Mika Kaneko, Toru Takahashi, Shojiro Motoyui   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Analytical solution of seismic power-based equation of motion

Heliyon
This research proposes an innovative power-based equation of motion (PBEM) for the single degree of freedom (SDOF) system considering seismic excitation.
Md Foisal Haque
doaj   +1 more source

Numerical studies on the seismic response of a three-storey low-damage steel framed structure incorporating seismic friction connections

Resilient Cities and Structures, 2023
A 9 m high, near full scale three-storey configurable steel frame composite floor building incorporating friction-based connections is to be tested using two linked bi-directional shake tables at the International joint research Laboratory of Earthquake ...
Zhenduo Yan, Shahab Ramhormozian, G. Charles Clifton, Rui Zhang, Ping Xiang, Liang-Jiu Jia, Gregory A. MacRae, Xianzhong Zhao   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Shaking table tests on spherical sliding bearings taking eccentricity and uplift into account

Japan Architectural Review, 2019
Although rubber bearings are popular in Japan as seismic isolation bearings, spherical sliding bearings (SSBs) or friction pendulum bearings are widely used in many countries, including the U.S.
Toru Takeuchi, Hideji Nakamura, Masakaze Uchida, Michiyasu Yoshida, Ryota Matsui   +4 more
doaj   +1 more source

Numerical simulation on seismic behavior of mechanical structure for electronic equipment with bolted joints

Nihon Kikai Gakkai ronbunshu, 2019
To stably operate electronic equipment such as computers and networking devices is essential to the current information society. They should be stably operated even when they are being subjected to seismic excitations. The computers and other devices are
Keisuke KANANO, Takuzo YAMASHITA, Daigoro ISOBE   +2 more
doaj   +1 more source