Results 41 to 50 of about 7,988,835 (298)

Motion analysis of furniture under seismic excitation using the finite element method

open access: yesJapan Architectural Review, 2018
Improperly secured furniture, especially on the upper floors of high‐rise buildings under long‐period ground motion, can prove dangerous to human life. Fallen items of furniture such as chairs and desks could become fatal obstacles that prevent efficient
Daigoro Isobe   +5 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Analytical solution of seismic power-based equation of motion

open access: yesHeliyon
This research proposes an innovative power-based equation of motion (PBEM) for the single degree of freedom (SDOF) system considering seismic excitation.
Md Foisal Haque
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Shaking Table Tests on Flow Dynamics in Liquefied Slope

open access: yesSoils and Foundations, 2004
A series of 1-g shaking-table model tests was carried out on lateral flow of a sandy slope undergoing high excess pore water pressure. Model sandy deposit of extremely low density was prepared in order to induce lateral flow to various extents whether with continued shaking or impact shaking of short duration.
TOYOTA, HlROFUMI   +3 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Shaking table tests on spherical sliding bearings taking eccentricity and uplift into account

open access: yesJapan Architectural Review, 2019
Although rubber bearings are popular in Japan as seismic isolation bearings, spherical sliding bearings (SSBs) or friction pendulum bearings are widely used in many countries, including the U.S.
Toru Takeuchi   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Numerical simulation on seismic behavior of mechanical structure for electronic equipment with bolted joints

open access: yesNihon Kikai Gakkai ronbunshu, 2019
To stably operate electronic equipment such as computers and networking devices is essential to the current information society. They should be stably operated even when they are being subjected to seismic excitations. The computers and other devices are
Keisuke KANANO   +2 more
doaj   +1 more source

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