Results 31 to 40 of about 7,099 (126)
Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning [PDF]
, 1998 A-type K+ channels are known to regulate neuronal firing, but their role in repetitive firing and learning in mammals is not well characterized. To determine the contribution of the auxiliary K+ channel subunit Kvbeta1.1 to A-type K+ currents and to ...
Fedorov, N. B. +7 more
core +1 more source
Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle +6 more
wiley +1 more source
The transporter-like protein inebriated mediates hyperosmotic stimuli through intracellular signaling [PDF]
, 2000 We cloned the inebriated homologue MasIne from Manduca sexta and expressed it in Xenopus laevis oocytes. MasIne is homologous to neurotransmitter transporters but no transport was observed with a number of putative substrates.
Chiu, Chi-Sung +4 more
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TRP Channels Entering the Structural Era [PDF]
, 2013 Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress in the use of structural biology techniques to elucidate molecular mechanisms of TRP channel ...
Gaudet, Rachelle
core +1 more source
FEBS Letters, Volume 600, Issue 4, Page 537-549, February 2026.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus. [PDF]
, 2007 I(Ks) channels contain four pore-forming KCNQ1 subunits and two accessory MinK subunits. MinK influences surface expression, voltage-dependence of gating, conduction, and pharmacology to yield the attributes characteristic of native channels in heart ...
Chen, Haijun, Goldstein, Steve AN
core
Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals [PDF]
, 2013 The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms.
Mourão, Caroline Barbosa Farias +1 more
core +3 more sources
Advanced Science, Volume 13, Issue 10, 18 February 2026.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. [PDF]
, 2000 Potassium leak conductances were recently revealed to exist as independent molecular entities. Here, the genomic structure, cardiac localization, and biophysical properties of a murine example are considered.
Buck, ME +4 more
core
Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. [PDF]
, 2004 Regulatory KChIP2 subunits assemble with pore-forming Kv4.2 subunits in 4:4 complexes to produce native voltage-gated potassium (Kv) channels like cardiac I(to) and neuronal I(A) subtypes. Here, negative stain electron microscopy (EM) and single particle
Butler, Margaret H +6 more
core