Results 41 to 50 of about 7,099 (126)
Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus [PDF]
, 2014 Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters ...
Clapham, David E +4 more
core +2 more sources
Disordered N‐termini enhance the thermostability of SGNH‐hydrolase family polyesterases
Protein Science, Volume 35, Issue 1, January 2026.Abstract Polyesters are widely used plastics that persist in the environment due to their resistance to degradation. Microbial polyesterases potentially offer recycling and remediation solutions. However, most polyesterases lack the thermostability and catalytic efficiency required for practical application.
F. Hafna Ahmed +7 more
wiley +1 more source
Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1 [PDF]
, 2015 Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment.
Comoletti, Davide +12 more
core +1 more source
Advanced Biology, Volume 9, Issue 12, December 2025.Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams +7 more
wiley +1 more source
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels [PDF]
, 2015 Voltage-gated ion channels (VGICs) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes.
Alessandro eMedoro +7 more
core +2 more sources
Advanced Science, Volume 12, Issue 45, December 4, 2025.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. [PDF]
, 2018 Kinesin-4 motors play important roles in cell division, microtubule organization, and signaling. Understanding how motors perform their functions requires an understanding of their mechanochemical and motility properties.
Blasius, T Lynne +7 more
core +2 more sources
Microglia Display Altered Spatial Morphology and Proteome After Stroke
PROTEOMICS, Volume 25, Issue 23, Page 59-76, December 2025.ABSTRACT Microglia are abundantly distributed throughout the central nervous system (CNS) to play critical roles in neural development and homeostasis, and act as immune sentinels to constantly monitor their surrounding neural environment. Given their high reactivity to brain insults, we hypothesised that the cerebral microenvironment altered by ...
Brooke J. Wanrooy +10 more
wiley +1 more source
Protein Science, Volume 34, Issue 12, December 2025.Abstract IM30, the inner membrane‐associated protein of 30 kDa (also known as Vipp1) is essential for thylakoid membrane biogenesis and/or maintenance in chloroplasts and cyanobacteria. IM30 and its bacterial homolog PspA belong to the ESCRT‐III superfamily, proteins previously thought to be restricted to eukaryotes and archaea.
Lukas Schlösser +16 more
wiley +1 more source
The Caenorhabditis elegans Iodotyrosine Deiodinase Ortholog SUP-18 Functions through a Conserved Channel SC-Box to Regulate the Muscle Two-Pore Domain Potassium Channel SUP-9 [PDF]
, 2013 Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore domain K+ channel associated with ...
de la Cruz, Ignacio Perez +2 more
core +2 more sources