European Journal of Neuroscience, Volume 62, Issue 11, December 2025.ABSTRACT The medial habenula–interpeduncular nucleus pathway is a highly conserved and densely innervated brain circuit known for its unique cholinergic transmission and exceptional expression of nicotinic acetylcholine receptors. This pathway plays a critical role in regulating motivational and emotional processes, particularly those related to ...
Maria Ciscato +2 more
wiley +1 more source
Structural rearrangements underlying ligand-gating in Kir channels [PDF]
, 2012 Inward rectifier potassium (Kir) channels are physiologically regulated by a wide range of ligands that all act on a common gate, although structural details of gating are unclear.
Enkvetchakul, Decha +4 more
core +3 more sources
Advanced Science, Volume 12, Issue 41, November 6, 2025.Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao +16 more
wiley +1 more source
Molecular Sensors and Modulators of Thermoreception [PDF]
, 2015 Peer ...
Zhang, Xuming
core +1 more source
Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles [PDF]
, 2013 RNA editing at the Q/R site near the apex of the pore loop of AMPA and kainate receptors controls a diverse array of channel properties, including ion selectivity and unitary conductance and susceptibility to inhibition by polyamines and cis-unsaturated ...
Boland +67 more
core +2 more sources
Ioncsatornák szerepe az immunrendszer sejtjeinek differenciálódásában és proliferációjában = The role of ion channels in differentiation and proliferation of immune cells. [PDF]
, 2007 Elektrofiziológiai és biokémiai módszerek kombinálásával számos új, potenciálisan immunszuppresszív hatású Kv1.3 ioncsatorna blokkoló toxint fedeztünk fel, melyeket a az Anurotonus phaiodactylus, a Centruroides elegans Thorell, a Centruroides suffusus ...
Bagdány, Miklós +4 more
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A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. [PDF]
, 1995 Potassium channels catalyse the permeation of K+ ions across cellular membranes and are identified by a common structural motif, a highly conserved signature sequence of eight amino acids in the P domain of each channel's pore-forming alpha-subunit. Here
Goldstein, SA +4 more
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Ventricular Action Potential Adaptation to Regular Exercise: Role of β-adrenergic and K\u3csub\u3eATP\u3c/sub\u3e Channel Function [PDF]
, 2017 Regular exercise training is known to affect the action potential duration (APD) and improve heart function, but involvement of β-adrenergic receptor (β-AR) subtypes and/or the ATP-sensitive K+ (KATP) channel is unknown.
Fitts, Robert H., Wang, Xinrui
core +1 more source
A PI3K-mediated negative feedback regulates Drosophila motor neuron excitability [PDF]
, 2008 Negative feedback can act as a homeostatic mechanism to maintain neuronal activity at a particular specified value. At the Drosophila neuromuscular junction, a mutation in the type II metabotropic glutamate receptor gene (mGluRA) increased motor neuron ...
Curtis C. J. Lin +3 more
core +1 more source
Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency. [PDF]
, 2019 Ninety percent of Americans consume less than the estimated average requirements of dietary vitamin E (vitE). Severe vitE deficiency due to genetic mutations in the tocopherol transfer protein (TTPA) in humans results in ataxia with vitE deficiency (AVED)
Bordbari, Matthew H +9 more
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