Results 131 to 140 of about 221,329 (275)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Correction to: Smoothness and Shape Preserving Properties of Bernstein Semigroup [PDF]

Mediterranean Journal of Mathematics, 2018
Sever Hodiş, Laura Mesaroş, Ioan Raşa
openaire   +1 more source

Shape preserving C2 interpolatory subdivision schemes [PDF]

, 1998
Stationary interpolatory subdivision schemes which preserve shape properties such as convexity or monotonicity are constructed. The schemes are rational in the data and generate limit functions that are at least $C^2$.
Kuijt, F., van Damme, Rudolf M.J.
core  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Shape-Preserving C¹ and C² Reconstructions of Discontinuous Functions Using Spline Quasi-Interpolation

Mathematics
This paper addresses fundamental challenges in numerical approximation methods, focusing on balancing accuracy with shape-preserving properties. We present novel approaches that combine traditional spline methods with modern numerical techniques ...
Francesc Aràndiga, Sara Remogna
doaj   +1 more source

Shape pattern recognition using a computable shape pattern representation [PDF]

, 1998
Properties of shapes and shape patterns are investigated in order to represent shape pattern knowledge for supporting shape pattern recognition. It is based on the notion that shape patterns are classified in terms of similarity of spatial relationships ...
M.Y. Cha, J.S. Gero
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Approximation and shape preserving properties by nonlinear Lupaş type Bernstein operators of max-product kind

Arabian Journal of Mathematics
The authors introduce nonlinear Lupaș type Bernstein operators of max-product kind based on \(q\)-integers. These operators have the endpoint interpolation property. Quasi-convexity, monotonicity and shape-preserving properties are studied.
Mohd Shanawaz Mansoori, Asif Khan, Khursheed J. Ansari   +2 more
openaire   +2 more sources