Results 121 to 130 of about 221,329 (275)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
3n-Point Quaternary Shape Preserving Subdivision Schemes [PDF]
Mehran University Research Journal of Engineering and Technology, 2017 In this paper, an algorithm is defined to construct 3n-point quaternary approximating subdivision schemes which are useful to design different geometric objects in the field of geometric modeling.
MEHWISH BARI +2 more
doaj
On Shape Preserving Smoothing Splines [PDF]
In many approximation problems it is important that solutions preserve some shape properties such as positivity, monotonicity and/or convexity. The additional shape preserving conditions are usually considered as the positivity/negativity constraints on ...
Asmuss, Svetlana, Budkina, Nataļja
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
An Optimal Property of B-Bases for the Modified Richardson Method
AxiomsA space with a normalized totally positive basis has a unique normalized B-basis. In computer-aided geometric design, normalized B-bases present optimal shape-preserving properties.
Juan Manuel Peña
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Functional fatigue in NiTi shape memory alloy wires - A comparative study [PDF]
, 2012 The functional fatigue behaviour of two near equi-atomic NiTi shape memory alloy wires obtained from different sources were evaluated. Results showed that though the wires had similar transformation temperatures and mechanical properties, their ...
Ramaiah, KV +3 more
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
On better approximation order for the max-product Meyer-König and Zeller operator
Demonstratio MathematicaBede et al. (B. Bede, L. Coroianu, and S. G. Gal, Approximation and shape preserving properties of the nonlinear Meyer-König and Zeller operator of max-product kind, Numer. Funct. Anal. Optim. 31 (2010), no.
Çit Sezin, Doğru Ogün
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source