Results 91 to 100 of about 4,605,857 (269)

A pipeline to morph finite element models of the lumbar spine for generation of customised spinal cages

Journal of Orthopaedic Surgery and Research
Background Lumbar interbody fusion with spinal cages is an established treatment for degenerative disc disease, however, generic cages comprising standardised shapes and sizes still encounter complications such as cage migration and subsidence ...
Yihang Yu, Dale L. Robinson, David C. Ackland, Peter Vee Sin Lee   +3 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Synthesizing gait motions from spline-based progression functions of controlled shape [PDF]

, 2019
Kinematic approaches of motion generation use joint angles of a specified kinematic skeleton to describe poses and consider motions as sequences of poses. The progression functions, i.e. the functions describing the angular values of the joints over time
Brunnett, Guido, Salamah, Samer, Mitschke, Christian, Heß, Tobias   +3 more
core   +2 more sources

A generic method to construct new customized-shaped haotic systems using the relative motion concept

Nonlinear Analysis: Modelling and Control, 2016
Constructing chaotic systems tailored for each particular real-world application has been a long-term research desideratum. We report a solution for this problem based on the concept of relative motion. We investigate the periodic motion on a closed contour of a coordinate frame in which a chaotic system evolves.
Daniel-Ioan Curiac, Constantin Volosencu
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

IAM: Identity-Aware Human Motion and Shape Joint Generation

Recent advances in text-driven human motion generation enable models to synthesize realistic motion sequences from natural language descriptions. However, most existing approaches assume identity-neutral motion and generate movements using a canonical body representation, ignoring the strong influence of body morphology on motion dynamics. In practice,
Jia, Wenqi, Li, Zekun, Mittal, Abhay, Tang, Chengcheng, Guo, Chuan, Wang, Lezi, Rehg, James Matthew, Tao, Lingling, An, Size   +8 more
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Generation of Plug-like Chromatographic Bands in Preparative Liquid Chromatographic Column by Using Conical Shape Wall Column.

, 2008
Generation of Plug-like Chromatographic Bands in Preparative Liquid Chromatographic Column by Using Conical Shape Wall ...
关亚风, 陈捷, 卢烈娟
core