Results 81 to 90 of about 4,605,857 (269)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

SHAPE-ID Toolkit Resources - Develop a Career in Inter- or Transdisciplinary Research

, 2021
Early-stage researchers, in particular, can receive very mixed messages about the wisdom of pursuing an inter- or transdisciplinary research career which is often regarded as high risk within a research system that is still primarily structured on ...
SHAPE-ID
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Cloth manipulation based on motion generation and shape prediction by EM*D-net

Transactions of the JSME (in Japanese), 2018
In this paper, we describe a motion planning method for cloth manipulation. We address the problem that only the current shape of the cloth product and its target shape are given. To accomplish this task, it is necessary to determine how to manipulate the cloth and to predict the manipulated shape of the cloth.
Daisuke TANAKA, Solvi ARNOLD, Kimitoshi YAMAZAKI   +2 more
openaire   +3 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Planning Motions for Shape-Memory Alloy Sheets

, 2015
through a series of feasible (non-colliding and gravitationally stable) intermediate states, like (c). (d) is infeasible, since it is not gravitationally stable. Shape Memory Alloys (SMAs) are smart materials that can remember predefined shapes.
Mukulika Ghosh, Samuel Rodriguez, Daniel Tomkins, Jory Denny, Marco Morales, Nancy M. Amato   +5 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Shape Machine and Interpreters

, 2019
Presented as part of the Shape Machine Symposium on April 11, 2019 at 10:34 a.m. in the John & Joyce Caddell Building, Flex Space.Tzu-Chieh Kurt Hong is a PhD candidate in the School of Architecture at the Georgia Institute of Technology.
Hong, Tzu-Chieh Kurt
core   +1 more source

Unconditional Human Motion and Shape Generation via Balanced Score-Based Diffusion

CoRR
Recent work has explored a range of model families for human motion generation, including Variational Autoencoders (VAEs), Generative Adversarial Networks (GANs), and diffusion-based models. Despite their differences, many methods rely on over-parameterized input features and auxiliary losses to improve empirical results. These strategies should not be
David Björkstrand, Tiesheng Wang, Lars Bretzner, Josephine Sullivan   +3 more
openaire   +3 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source