Results 71 to 80 of about 4,605,857 (269)

PEUSP-beta: a web-based ground motion record selection platform for seismic safety assessment

SoftwareX
The selection and scaling of ground motions is a key step in the seismic assessment of structures, as it directly affects the reliability of nonlinear response analyses and performance-based evaluations.
Daniel Caicedo, Shaghayegh Karimzadeh, Vasco Bernardo, Paulo B. Lourenço   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The role of the A428D mutation in conferring resistance to pirtobrutinib in Bruton's tyrosine kinase: insights from molecular dynamics simulations

Results in Chemistry
Acquired resistance to non-covalent, reversible Bruton's tyrosine kinase (BTK) inhibitors poses a major therapeutic challenge in B-cell malignancies, yet the underlying biophysical mechanisms remain poorly understood.
Biyu Xu, Han Gao, Yirong Jiang, Damin Luo, Chunlai Fu, Zuguo Zhao   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Motions of Curves in the Projective Plane Inducing the Kaup-Kupershmidt Hierarchy [PDF]

, 2012
The equation of a motion of curves in the projective plane is deduced. Local flows are defined in terms of polynomial differential functions. A family of local flows inducing the Kaup-Kupershmidt hierarchy is constructed.
Musso, Emilio, Emilio Musso, Musso, E.
core   +1 more source

Computerized Generation of Endodontic Files by Reproducing the Flute Grinding Manufacturing Process

Bioengineering
Background: File fracture during root canal treatment in endodontics is a major concern for clinicians. The strength of the file is strongly dependent on its geometry, material, and working conditions; finite element simulations are used to understand ...
Victor Roda-Casanova, Antonio Pérez-González   +1 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Poverty Traps and Business Cycles in a Stochastic Overlapping Generations Economy with S-Shaped Law of Motion [PDF]

Journal of Macroeconomics, 2002
This paper contributes to the understanding of stochastic economic dynamics with S-shaped law of motion. Applying random dynamical systems theory, we obtain a complete analysis of a stochastic OLG growth model. In the long-run the economy converges either to a state with no capital (poverty trap) or a sample path of a random fixed point (business cycle)
openaire   +4 more sources