Results 41 to 50 of about 2,232 (295)

Languages of flexibility: : Digital grammars of architecture, 1970s [PDF]

open access: yes, 2021
At the same time that flexibility was being constructed as the potential to rearrange, repurpose and even reclaim spaces within modernism, the 1960s and 70s saw the technical concretisation of a parallel conception of design as an open system, into a ...
Miranda Carranza, Pablo,
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Extraction and evaluation of transportation network grammars for efficient planning applications

open access: yesDesign Science, 2018
Grammars, with their generic approach and broad application potential in many planning fields, are accepted as adaptable and efficient tools for design and planning applications, bridging design rules and technical planning requirements.
B. J. Vitins, K. W. Axhausen
doaj   +1 more source

Shape grammars for architectural design: the need for reframing [PDF]

open access: yes, 2015
Although many shape grammars and corresponding implementations have been proposed, shape grammars are not widely adopted by architectural designers.
De Meyer, Ronald   +7 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Computational Design and Service Learning in Informal Settlement Planning: A Pedagogical Model for Architectural Education

open access: yesBuildings
Rapid urbanization in the Global South continues to intensify the growth of informal settlements, challenging architectural education to equip students with methods capable of addressing complex socio-spatial, environmental, and ethical conditions. While
Fernando Lima   +3 more
doaj   +1 more source

Engineering Grammar-Based Type Checking for Graph Rewriting Languages

open access: yesIEEE Access, 2022
The ability to handle evolving graph structures is important both for programming languages and modeling languages. Of various languages that adopt graphs as primary data structures, a graph rewriting language LMNtal provides features of both (concurrent)
Naoki Yamamoto, Kazunori Ueda
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, Volume 16, Issue 8, Page 1452-1458, August 2026.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Computation-friendly shape grammars [PDF]

open access: yes, 2018
NP-hardness of parametric subshape recognition for an arbitrary number of open terms is proven. Guided by this understanding of the complexity of subshape recognition, a framework for computation-friendly parametric shape grammar interpreters is proposed,
Kui Yue (5047310)   +2 more
core   +1 more source

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