Results 111 to 120 of about 451,392 (314)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Optimal variable shape parameter for multiquadric based RBF-FD method [PDF]

open access: yes, 2012
In this follow up paper to our previous study in Bayona et al. (2011) [2], we present a new technique to compute the solution of PDEs with the multiquadric based RBF finite difference method (RBF-FD) using an optimal node dependent variable value of the ...
Manuel Kindelan   +5 more
core   +1 more source

A New Radial Basis Function Approach Based on Hermite Expansion with Respect to the Shape Parameter

open access: yesMathematics, 2019
Owing to its high accuracy, the radial basis function (RBF) is gaining popularity in function interpolation and for solving partial differential equations (PDEs).
Saleh Abobakur Bawazeer   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Object-based video representations: shape compression and object segmentation [PDF]

open access: yes, 1998
Object-based video representations are considered to be useful for easing the process of multimedia content production and enhancing user interactivity in multimedia productions.
Brady, Noel
core  

A study of Weibull shape parameter: Properties and significance

open access: yes, 2011
The two-parameter Weibull distribution has been widely used for modelling the lifetime of products and components. In this paper we study the effect of the shape parameter on the failure rate and three variables of importance in the context of ...
Murthy, D. N. P.   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Finding an Effective Shape Parameter Strategy to Obtain the Optimal Shape Parameter of the Oscillatory Radial Basis Function Collocation in 3D

open access: yes, 2022
Recent research into using the Method of Approximate Particular Solutions to numerically solve partial differential equations, has shown promising results. High levels of accuracy can be obtained when implementing this method, however the success of this
Aiken, Quinnlan   +2 more
core  

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