Results 131 to 140 of about 451,392 (314)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Bézier Curves with Shape Parameter
, 2006 给出了n+1(n≥1)次带形状参数的多项式调配函数,n次Bézier曲线的基函数是它的一特例.由给出的调配函数,建立了带形状参数的分段多项式曲线生成方法.研究了所生成曲线及其调配函数的性质.其调配函数具有权性和非负性;曲线的性质如端点性质、对称性、凸包性、几何不变性等与bézier曲线的性质类似.研究结果表明:在控制多边形不变的情况下,可以通过改变形状参数的值来调整曲线的形状,随着次数的升高,可调形状参数的取值范围将扩大.A class of blending function of degree n ...
曾晓明, 程黄和
core
, 2013 Figure 1. Weibull shape parameter k (a), scale parameter λ (b), and histogram of the Weibull shape parameter in seven regions and globally (c). A large shape parameter indicates a narrower distribution compared to a lower shape parameter.
Steven J Smith (557081) +1 more
core +1 more source
Assessing accuracy of Weibull shape parameter estimate from historical studies for subsequent sample size calculation in clinical trials with time-to-event outcome. [PDF]
Contemp Clin Trials Commun, 2020 Phadnis MA +3 more
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Statistical Inference on the Shape Parameter of Inverse Generalized Weibull Distribution
MathematicsIn this paper, we propose statistical inference methodologies for estimating the shape parameter α of inverse generalized Weibull (IGW) distribution. Specifically, we develop two approaches: (1) a bounded-risk point estimation strategy for α and (2) a ...
Yan Zhuang, Sudeep R. Bapat, Wenjie Wang
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
What is the actual shape of perception utility?
Cumulative Prospect Theory (Kahneman, Tversky, 1979, 1992) holds that the value function is described using a power function, and is concave for gains and convex for losses.
Kontek, Krzysztof
core
Parameter-free testing of the shape of a probability distribution
, 2007 The Kolmogorov-Smirnov test determines the consistency of empirical data with a particular probability distribution. Often, parameters in the distribution are unknown, and have to be estimated from the data.
Jonathan Bacon (4460323) +3 more
core