Results 81 to 90 of about 2,325,002 (342)

Shared decision-making and patient decision aids in dermatology [PDF]

, 2016
Shared decision making combines individual patient interests and values with clinical best evidence under the guiding principle of patient autonomy. Patient decision aids can support shared decision making and facilitate decisions that have multiple ...
Albrecht, Elwyn, Graham, Haynes, Kiesler, Stacey, Stacey, Tan, Tan, Tan, Towle, Walter   +11 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Impact of timing and format of patient decision aids for breast cancer patients on their involvement in and preparedness for decision making - the IMPACTT randomised controlled trial protocol

BMC Cancer
Background After curative surgery for early-stage breast cancer, patients face a decision on whether to undergo surgery alone or to receive one or more adjuvant treatments, which may lower the risk of recurrence. Variations in survival outcomes are often
Bettina Mølri Knudsen, Stine Rauff Søndergaard, Dawn Stacey, Karina Dahl Steffensen   +3 more
doaj   +1 more source

Deciding Together?:Best Interests and Shared Decision-Making in Paediatric Intensive Care [PDF]

, 2014
In the western healthcare, shared decision making has become the orthodox approach to making healthcare choices as a way of promoting patient autonomy.
A Buchanan, A Payot, AGM Campbell, B Lyons, C Charles, C Munthe, D Archard, D DeGrazia, D Nichols, D Wilkinson, D Wilkinson, DS Diekema, DS Diekema, E Kluge, EJ Emanuel, G Colville, Giles Birchley, H Brody, H Harrison, J Bridgeman, J Brierley, J Eekelaar, J Eekelaar, J Harris, J Herring, J Plante, J Rawls, J Savulescu, JD Moreno, K Costeloe, K Strong, L Bibbings, L Sandman, L Sandman, L Sandman, LA Hansen, LF Ross, LM Kopelman, LM Kopelman, Lord Woolf, LT Singer, LT Singer, M Benjamin, M Fox, M Jonas, Nuffield Council on Bioethics, P Baines, P Biegler, R Gilbar, R Gilbar, R Huxtable, R Ladd, R Miller, R Sizemore, RB Miller, RD Truog, Royal College of Paediatrics and Child Health, S Choudhry, S Choudhry, S Elliston, S Holm, S Holm, S Saigal, T Nagel, TG Gutheil, V Larcher, V Zamvar, W Morris   +67 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Empowering Effective Teachers: Readiness for Reform [PDF]

, 2010
Outlines a spectrum of conditions needed for the successful implementation of teacher effectiveness reform, including shared leadership, vision, and commitment; a culture of data-driven decision making; stakeholder engagement; and supportive ...

core  

Retrieval of publications addressing shared decision making: an evaluation of full-text searches on medical journal websites. [PDF]

, 2015
BACKGROUND: Full-text searches of articles increase the recall, defined by the proportion of relevant publications that are retrieved. However, this method is rarely used in medical research due to resource constraints.
Auer, R., Blanc, X., Clair, C., Collet, T.H., Cornuz, J., Iriarte, P., Krause, J., Légaré, F.   +7 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Efficacy of shared decision making on treatment satisfaction for patients with first-admission schizophrenia: study protocol for a randomised controlled trial [PDF]

, 2014
BACKGROUND: Shared decision making is a promising model for patient-centred medicine, resulting in better clinical outcomes overall. In the mental health field, interventions that consider the patient-centred perspective—such as patient quality of life ...
Hana Hasegawa, Hiroto Ito, Mio Ishii, Naoya Sugiyama, Toshie Noda, Yasuyuki Okumura, Yoshio Hirayasu   +6 more
core   +2 more sources