Results 91 to 100 of about 3,563,944 (406)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Patient centred diagnosis: sharing diagnostic decisions with patients in clinical practice. [PDF]

, 2017
Patient centred diagnosis is best practised through shared decision making; an iterative dialogue between doctor and patient, whichrespects a patient’s needs, values, preferences, and circumstances.
Berger, Zackary, Brito, J. P., Haskell, H., Hess, Ep, Hinson, Js, Kannan, S., Montori, V. M., Newman-Toker, D., Ospina, Ns   +8 more
core  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Re-­Thinking Shared Decision‐Making: Context Matters [PDF]

, 2013
Objective Traditional perspectives on shared decision-making (SDM) focus attention on the point in a clinical encounter where discussion of a treatment decision begins. We argue that SDM is shaped not only by initiation of a treatment decision, but also
Frankel, Richard M., Matthias, Marianne S., Salyers, Michelle P.   +2 more
core   +1 more source

Shared Decision-Making in Pancreatic Surgery

Annals of Surgery Open, 2022
Objective:. The objective of this study is to determine the factors influencing pancreatic surgery patients’ perceptions of the shared decision-making process (SDM). Background:.
Jennifer Trobaugh, MS, Wayne Fuqua, PhD, Kyra Folkert, MD, Sarah Khalil, MD, Saad Shebrain, MD, Gitonga Munene, MD   +5 more
doaj   +1 more source

Inter-professional shared decision making – increasing the “shared” in shared decision making

International Journal of Healthcare, 2015
Shared decision making (SDM) has been shown to increase patient engagement, patient satisfaction and adherence to treatment. Yet SDM remains underutilized in primary care due to factors such as the additional time required to implement, particularly for individual physicians.
Jessica Stewart, Michael E. Johansen, Cynthia J. Sieck   +2 more
openaire   +3 more sources

Seeing eye to eye: social augmented reality and shared decision making in the marketplace

Journal of the Academy of Marketing Science, 2019
Firms increasingly seek to improve the online shopping experience by enabling customers to exchange product recommendations through social augmented reality (AR).
Tim Hilken, D. Keeling, Ko de Ruyter, D. Mahr, Mathew B. Chylinski   +4 more
semanticscholar   +1 more source

Historical Perspectives: Shared Decision Making in the NICU.

NeoReviews, 2020
The ethical dilemmas and predominant frameworks surrounding decision making for critically ill newborns have evolved substantially over the last 40 years.
A. Sullivan, C. Cummings
semanticscholar   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

The ICC’s witness protective measures through the lens of policy-oriented jurisprudence [PDF]

, 2015
The protection of witnesses from intimidation or harm has become a firmly entrenched part of modern criminal justice systems. The ICC’s decision-making with regard to procedural and non-procedural protective measures has on one hand reinforced the ...
Kayuni, Steven William
core   +2 more sources