Results 81 to 90 of about 6,673,862 (248)

INTERPROFESSIONAL SHARED DECISION-MAKING: A LITERATURE REVIEW

Jurnal Pendidikan Kedokteran Indonesia, 2020
Background: The increasing complexity of health problems consequently demands problem solving from various perspectives of health professionals. The interprofessional approach in solving health problems, by working together with patients, their families,
Chaina Hanum, Ardi Findyartini
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Exploration of between-hospital variation and the basis for decision making in management of malignant colorectal polyps- a Danish population-based study

World Journal of Surgical Oncology
Background Finding an unexpected carcinoma in an endoscopically resected colorectal polyp poses a dilemma regarding the subsequent management strategy. Proceeding to surgery with formal segmental bowel resection is associated with a low recurrence risk ...
Helene Juul Würtz, Lea Lund, Jan Lindebjerg, Karina Dahl Steffensen, Adrian Edwards, Hans B. Rahr   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The very idea of shared decision-making: views from social science [PDF]

, 2003
Aim: To examine the ‘idea of shared decision making focusing on assumptions about the concepts ‘choice’ and ‘decision making’;\ud \ud Content: Much of the research literature on shared decision making relies on a prioi assumptions about concepts of ...
Hepworth, Julie, Murtagh, M.J., Rapley, Timothy   +2 more
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Validation of Pre-Adolescent Decision-Making Competence in Turkish students

, 2019
The objective of this study was to adapt the Pre-Adolescent Decision-Making Competence Test to Turkish, which was originally developed in English by Weller, Levin, Rose and Bossard (2012) for assessing decision-making competence of children between the ...
Cevik, Yasemin Demiraslan and Dogan, Nuri and Daghan, Gokhan and Mumcu, Filiz Kuskaya and Somyurek, Sibel and Karaman, Haydar
core  

Empowering women considering reconstructive breast surgery – a Danish cohort study on decisional conflict and regret

Journal of Plastic Surgery and Hand Surgery
Backround: Breast reconstructive surgery following mastectomy or lumpectomy presents a significant decisional challenge for patients. The emotional weight of a cancer diagnosis and the complexity of surgical options necessitate a comprehensive support ...
Bekka Christensen, Karina Steffensen, Anna Mejldal, Vibeke Koudahl   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source