Results 91 to 100 of about 6,673,862 (248)

Antibiotic and shared decision-making preferences among adolescents in Malaysia

, 2015
Irma Wati Ngadimon, Farida Islahudin, Ernieda Hatah, Noraida Mohamed Shah, Mohd Makmor-Bakry Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: The purpose of this study was to establish baseline information on the ...
Hatah E, Makmor-Bakry M, Ngadimon IW, Islahudin F, Mohamed Shah N   +4 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Working in partnership: the application of shared decision making to health visitor practice [PDF]

, 2017
Aim and objectives To explore the processes which support shared decision making when health visitors and parents are creating plans to improve the wellbeing of babies and children.  Background  Worldwide, there is a focus on promoting children'
Astbury, Ruth, Cheyne, Helen, Shepherd, Ashley   +2 more
core   +1 more source

The decision paradoxes motivating Prospect Theory : The prevalence of the paradoxes increases with numerical ability

, 2019
Prospect Theory (PT: Kahneman & Tversky, 1979) of risky decision making is based on psychological phenomena (paradoxes) that motivate assumptions about how people react to gains and losses, and how they weight outcomes with probabilities.
Nilsson, Håkan, Juslin, Peter, Millroth, Philip   +2 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Towards generic online multicriteria decision support in patient-centred health care. [PDF]

, 2013
OBJECTIVE: To introduce a new online generic decision support system based on multicriteria decision analysis (MCDA), implemented in practical and user-friendly software (Annalisa©). BACKGROUND: All parties in health care lack a simple and generic way to
Salkeld, Glenn, Jack Dowie, Kaltoft, Mette Kjer, Kjer Kaltoft, Mette, Dowie, Jack, Michelle Cunich, Mette Kjer Kaltoft, Cunich, Michelle, Glenn Salkeld   +8 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source