Results 121 to 130 of about 3,563,944 (406)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial. [PDF]

, 2016
OBJECTIVE: To compare the effectiveness of shared decision making with usual care in choice of admission for observation and further cardiac testing or for referral for outpatient evaluation in patients with possible acute coronary syndrome.
Castaneda-Guarderas, Ana, Demers, Michel, Diercks, Deborah B., Herrin, Jeph, Hess, Erik P., Hollander, Judd E., Inselman, Jonathan, Jones, Russell, Kline, Jeffrey A., Leblanc, Annie, Meisel, Zachary F., Montori, Victor M., Owen, Kelly P., Schaffer, Jason T., Shah, Nilay D., Torres, Carlos A.   +15 more
core   +3 more sources

Predicting acute odynophagia during lung cancer radiotherapy using observations derived from patient-centred nursing care

Technical Innovations & Patient Support in Radiation Oncology, 2018
During radiotherapy, lung cancer patients commonly experience pain while swallowing (odynophagia) of food and drink. Observations from patient-centred nursing practice have been used to generate predictive models for odynophagia needing prescription pain
Karina Olling, Dorte Wendelboe Nyeng, Leonard Wee   +2 more
doaj  

Strategies to facilitate shared decision‐making in long‐term care

International Journal of Older People Nursing, 2020
Aim The aim of this study was to explore shared decision‐making among residents, their families and staff to determine relevant strategies to support shared decision‐making in long‐term care (LTC). Background Meaningful engagement of long‐term care home (
L. Cranley, S. Slaughter, Sienna Caspar, Melissa Heisey, Mei-Chih Huang, T. Killackey, K. McGilton   +6 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Retrieval of publications addressing shared decision making: an evaluation of full-text searches on medical journal websites. [PDF]

, 2015
BACKGROUND: Full-text searches of articles increase the recall, defined by the proportion of relevant publications that are retrieved. However, this method is rarely used in medical research due to resource constraints.
Auer, R., Blanc, X., Clair, C., Collet, T.H., Cornuz, J., Iriarte, P., Krause, J., Légaré, F.   +7 more
core   +3 more sources

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Parents’ Perspectives on Shared Decision Making for Children With Solid Organ Transplants [PDF]

, 2016
Introduction The Institute of Medicine prioritizes active family and clinician participation in treatment decisions, known as shared decision making (SDM).
Haglund, Kristin, Johnson, Norah L., Lerret, Stacee M.   +2 more
core   +1 more source

Factors influencing patients’ preferences and perceived involvement in shared decision making in mental health care [PDF]

, 2014
Background: Although research has suggested that patients desire to participate in shared decision-making, recent studies show that most patients take a passive role in their treatment decisions.
Eliacin, Johanne, Kukla, Marina, Matthias, Marianne S., Salyers, Michelle P.   +3 more
core   +1 more source

Evaluating Shared Decision Making for Lung Cancer Screening

JAMA Internal Medicine, 2018
Importance The US Preventive Services Task Force recommends that shared decision making (SDM) involving a thorough discussion of benefits and harms should occur between clinicians and patients before initiating lung cancer screening (LCS) with low-dose ...
Alison R. T. Brenner, T. Malo, M. Margolis, Jennifer Elston Lafata, Shynah James, Maihan B Vu, D. Reuland   +6 more
semanticscholar   +1 more source