Results 151 to 160 of about 2,301,345 (296)

Factors associated with oncology patients' involvement in shared decision making during chemotherapy [PDF]

, 2016
Colley, Alexis, Dunn, Laura B, Halpern, Jodi, Hammer, Marilyn J, Lahiff, Maureen, Levine, Jon D, Mastick, Judy, Miaskowski, Christine, Micco, Guy, Paul, Steven, Wright, Fay   +10 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Shared decision-making in radiotherapy for rectal cancer - A systematic review. [PDF]

Tech Innov Patient Support Radiat Oncol
Schou LK, Kristensen AW, Steffensen JH, Guren MG, Poulsen LØ, Spindler KG, Skovhus Kronborg CJ.   +6 more
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Machine Learning-Based Audiovisual Phenotyping for Measuring Communication, Shared Decision-Making, and Trust. [PDF]

JMIR Form Res
Khaikin S, Tiruvadi V, Brooks J, Baird A, Grela-Mpoko AC, Hoffman L, Crossley J, Leasy M, Fineman J, Savoy M, Igarabuza L, Paranjape A, Foo CY, Birnbaum ML, Zisman-Ilani Y.   +14 more
europepmc   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Shared Decision-Making with Palliative Care Specialist. [PDF]

J Hosp Palliat Care
Huang HL.
europepmc   +1 more source

Behavioural finance and immersive games: a pan-European framework for design and evaluation

, 2009
This paper describes the development of a Design and Evaluation framework that aims to help stakeholders of a inter-disciplinary research project develop a shared understanding of project goals and methods by pooling their knowledge of research ...
Clough, Gill, Conole, Gráinne, Scanlon, Eileen   +2 more
core   +1 more source