Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
From Paper to Pixels: Digital Transition of a Patient Decision Aid—A Pilot Study
Mayo Clinic Proceedings: Digital HealthObjective: To convert a generic paper-based patient decision aid (PtDA) into digital format and assess its usability through α and β testing, recognizing the growing role of digital health technologies in empowering patients in shared decision-making ...
Bettina Mølri Knudsen, MA +4 more
doaj
Evaluation of two methods to facilitate shared decision making for men considering the prostate-specific antigen test [PDF]
, 2001 Dominick L. Frosch +2 more
openalex +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Cómo mejorar la comprensión y comunicación de información sobre riesgos médicos y salud [PDF]
, 2014 Informed and shared decision making require that people understand health risks. Unfortunately, many people are not risk literate and are biased by common risk communication practices.
García-Retamero Imedio, Rocío
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Impact of Cost Conversation on Decision-Making Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2021 Objective: To understand the impact of cost conversations on the following decision-making outcomes: patients’ knowledge about their conditions and treatment options, decisional conflict, and patient involvement.
Nataly R. Espinoza Suarez, MD +4 more
doaj
Evaluation of the quality of patient information to support informed shared decision‐making [PDF]
, 2001 William Godolphin +2 more
openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Modeling the University Decision Process: The Effects of Faculty Participation in University Decision Making [PDF]
This paper develops models of decision making in a university setting with and without faculty participation. The models predict values for the level of services or programs offered and the quality of those services in a university setting for either ...
Jane E. Ruseski +2 more
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Artificial Intelligence and Patient-Centered Decision-Making [PDF]
, 2020 Advanced AI systems are rapidly making their way into medical research and practice, and, arguably, it is only a matter of time before they will surpass human practitioners in terms of accuracy, reliability, and knowledge.
Bjerring, Jens Christian, Busch, Jacob
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