Results 91 to 100 of about 755,905 (296)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Governing Board Accountability: Competition, Regulation and Accreditation [PDF]

open access: yes, 2010
This article examines the three primary ways in which the governing boards of American colleges and universities are held to account: (1) competition; (2) regulation, including state nonprofit corporation laws, tax laws, and licensing laws; and (3 ...
Areen, Judith C.
core   +1 more source

Governing individual knowledge-sharing behaviour

open access: yesInternational Journal of Strategic Change Management, 2010
The emerging Knowledge Governance Approach asserts the need to build microfoundations grounded in individual action. Toward this goal, using the Theory of Planned Behavior, we aim to explain individual knowledge sharing behavior as being determined by the intention to share knowledge and its antecedents: attitude toward knowledge sharing, subjective ...
Minbaeva, Dana, Pedersen, Torben
openaire   +3 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

Give it up for climate change : a defence of the beneficiary pays principle [PDF]

open access: yes, 2012
This article focuses on the normative problem of establishing how the burdens associated with implementing policies designed to prevent, or manage, climate change should be shared amongst states involved in ongoing international climate change ...
Birks   +16 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Urban governance and planning for Economic growth [PDF]

open access: yes
Governance in short is a shift from bureaucratic process to shared power for the people. Governance in the urban areas goes hand in hand with planning. Issues of governance cannot be dealt with completely without proper planning. However, planning in the
Baafi Antwi, Joseph   +1 more
core   +1 more source

People and Oceans: Managing Marine Areas for Human Well-Being [PDF]

open access: yes, 2011
This booklet demonstrates an awakening within the conservation community that the human relationship with coastal and ocean environments must be evaluated in cultural, social, and economic -- as well as ecological -- dimensions.
Giselle Samonte   +2 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Relationship between nurses' perception of professional shared governance and their career motivation: A cross-sectional study. [PDF]

open access: yesInt J Nurs Sci, 2023
Ghanem Atalla AD   +5 more
europepmc   +1 more source

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