Results 91 to 100 of about 86,685 (296)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Sharp injuries to blood-borne pathogens among healthcare workers and influencing factors in a tertiary specialist hospital (2019–2022): a retrospective study

Scientific Reports
To assess the prevalence of sharp injuries among healthcare workers (HCWs) in a tertiary specialist hospital and analyze the influencing factors to improve protective measures and mitigate exposure risks.
Yuanyi Ji, Xiaoling Liu, Guishuang Song, Qiaolan Liu, Ruixin He, Yongzhong Cheng   +5 more
doaj   +1 more source

Attitude Control Method and Model Test for the Wave-Absorbing Buoy of the Sharp Eagle Wave Energy Converter Under All-Sea-State Operations

Journal of Marine Science and Engineering
As a critical component of marine renewable energy, wave energy has long remained a focal point in research on development and use. The Sharp Eagle wave energy converter (hereafter, Sharp Eagle WEC) exhibits wave energy capture efficiency-related ...
Kunlin Wang, Peifan Chen, Yin Ye, Wensheng Wang, Yaqun Zhang, Songwei Sheng   +5 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Sharp spatially constrained inversion

, 2013
We present sharp reconstruction of multi-layer models using a spatially constrained inversion with minimum gradient support regularization. In particular, its application to airborne electromagnetic data is discussed.
Fiandaca G., Christiansen A. V., Auken E., Vignoli G., Kirkegaard C.   +4 more
core  

Focusing Nanocrystal Size Distributions via Production Control

, 2016
We present a theoretical description of how continuous monomer production affects the focusing of nanocrystal size distributions in solution. We show that sufficiently high monomer production rates can drive a decrease in the polydispersity even as the ...
Sanat K. Kumar (1268259), Jonathan S. Owen (1281966), Michael D. Clark (765293), Emory M. Chan (1341054)   +3 more
core   +1 more source

Remarkable Recovery After Delayed High‐Dose Methylprednisolone in a Rare Case of Penetrating Spinal Cord Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Traumatic spinal cord injury (TSCI) caused by sharp‐force penetration is exceptionally rare, and the use of high‐dose methylprednisolone (MP) remains highly controversial, especially beyond the conventional 8‐h treatment window. This case report describes a 30‐year‐old male with acute incomplete TSCI following a knife stab wound to the right ...
Honghong Wang, Shuang Liu, Jiale Wang, Kaiyang Xue, Shenwei Li, Zhongheng Du   +5 more
wiley   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Passive Continuous Particle Focusing in a Microchannel with Symmetric Sharp Corner Structures

, 2014
We report a continuous passive particle focusing method using a novel microchannel with symmetric sharp corners which induce curved streamlines and large centrifugal force on particles.
Yu, Hand, He, Xu-Kun, Zhe, Jiang, Zhao, Liang, Fan, Liang-Liang, Wei, Qing-Yu   +5 more
core