Results 41 to 50 of about 78,093 (245)
Beams with the transverse-only intensity at the focus
Компьютерная оптикаIn this work, sharp focusing of vector beams with azimuthal polarization and beams with V-line of polarization uncertainty is simulated numerically using the Richards-Wolf formulas.
S.S. Stafeev, N.N. Kazakov, V.V. Kotlyar
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Helicity of Poincaré beams at the sharp focus
Компьютерная оптикаIn this study, helicity of Poincaré beams was considered from the point of view of the Richards-Wolf formalism. It was shown that helicity for Poincaré beams always has radial symmetry and does not depend on the azimuthal angle of the beam.
S.S. Stafeev, V.D. Zaitsev
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Focusing a Vortex Laser Beam with Polarization Conversion
Photonics, 2021 We show that when strongly focusing a linearly polarized optical vortex with the topological charge 2 (or −2) in the near-focus region, there occurs not only a reverse energy flow (where the projection of the Poynting vector is negative) but the right ...
Victor V. Kotlyar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Sharp Power Mean Bounds for Two Seiffert-like Means
Axioms, 2023 The mean is a subject of extensive study among scholars, and the pursuit of optimal power mean bounds is a highly active field. This article begins with a concise overview of recent advancements in this area, focusing specifically on Seiffert-like means.
Zhenhang Yang, Jing Zhang
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Sharp dose profiles for high precision proton therapy using strongly focused proton beams
Scientific Reports, 2022 AbstractThe main objective of radiotherapy is to exploit the curative potential of ionizing radiation while inflicting minimal radiation-induced damage to healthy tissue and sensitive organs. Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation.
Reaz, Fardous +4 more
openaire +4 more sources