Results 51 to 60 of about 86,685 (296)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
High-resolution computer simulation of electrophoretic mobilization in isoelectric focusing
, 2008 Cationic and anionic electrophoretic mobilization for focusing of hemoglobins (Hb's) in the presence of 100 carrier ampholytes covering a pI range of 6.00-7.98 was studied by computer simulation at a constant current density of 300 A/m(2 ...
Thormann, Wolfgang, Mosher, Richard A
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Adiabatic nano-focusing of plasmons by metallic tapered rods in the presence of dissipation
, 2007 We investigate the effect of dissipation on adiabatic nano-focusing of surface plasmons in a sharp metal tapered rod. Three distinct patters of nano-focusing and local field enhancement are predicted at different levels of dissipation and/or taper angles.
Vogel, Michael W., Gramotnev, Dmitri K.
core +1 more source
Threshold scattering for the focusing NLS with a repulsive potential
, 2023 We adapt the arguments in the recent work of Duyckaerts, Landoulsi, and Roudenko to establish a scattering result at the sharp threshold for the 3d focusing cubic NLS with a repulsive potential.
Jason Murphy +5 more
core +1 more source
Sharp focusing of light using a planar gradient microlens
Computer Optics, 2016 It is shown numerically that using planar gradient microlenses, the coherent radiation can be focused in a narrow line of width λ/38 and length λ/5.5. The efficiency of focusing is 22%. A slitted photonic-crystal lens retains the properties of sharp focusing of light characteristic of a gradient lens.
A. Nalimov, V. Kotlyar
openaire +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Regularized magnetotelluric inversion based on a minimum support gradient stabilizing functional
Earth, Planets and Space, 2017 Regularization is used to solve the ill-posed problem of magnetotelluric inversion usually by adding a stabilizing functional to the objective functional that allows us to obtain a stable solution.
Yang Xiang +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source