Results 191 to 200 of about 22,230 (251)

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Spatially Characterized Aortic Proteome Reveals Novel Regional Signatures and Glucocorticoid Receptor/Dipeptidase 1 Axis in Diabetic Vasculopathy. [PDF]

MedComm (2020)
Cheng CK, Meng S, Li T, Ding H, Jiang M, Tian Z, Ng CF, Xia Y, Offermanns S, Huang Y.   +9 more
europepmc   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

Stress Deflection Effect and Rockburst Mechanism in Staggered Roadways Beneath "L-Shaped" Residual Pillar. [PDF]

Sensors (Basel)
Lu Q, Jin J, Gong S, Li H, Zhang R, Chen B, Qu Y, Mu Z.   +7 more
europepmc   +1 more source

Unlocking Strength‐Toughness Dilemma in High‐Entropy Borides by Intragranular Microstructural Reconstruction

Advanced Science, EarlyView.
An extreme non‐equilibrium process combining heavy direct current sintering and TiSi2 addition is used to construct intragranular energy dissipation units within high‐entropy boride ceramics to overcome the strength‐toughness trade‐off. The resulting ceramic demonstrates attractive mechanical properties with a flexural strength of 887 MPa and a ...
Yingjun Liu, Yuhan Yao, Yufei Zu, Zhaofu Zhang, Yang Zhang, Hongfeng Dong, Nan Zhang, Wuhao Cao, Lehao Liu, Yuan Hu, Ruiheng An, Wenhu Li, Luyi Zhu, Taotao Ai   +13 more
wiley   +1 more source

Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation. [PDF]

Cell Commun Signal
Pabst A, Brock N, Hardt S, Grannemann CCF, Kubiza H, Thiebes AL, Ludwig A, Babendreyer A.   +7 more
europepmc   +1 more source

Large Language Model‐Informed Dual‐Track AI Framework for the Synergistic Design of Crack‐Free and High‐Strength Superalloys

Advanced Science, EarlyView.
This paper illustrates a knowledge‐augmented dual‐track AI framework for advanced superalloy design. First, Large Language Models translate metallurgical heuristics into explicit rules to rapidly prune a vast compositional search space. Subsequently, LLM‐distilled priors safely guide a reinforcement learning agent during autonomous process optimization,
Jian Yao, Junkang Wu, Jie Su, Fuzhu Wang, Zi Wang, Li Wang, Liming Tan, Lan Huang, Feng Liu, Yong Liu   +9 more
wiley   +1 more source

Heyde Syndrome: A Literature Review. [PDF]

Health Sci Rep
Gupta Y, Khan ARS, Shetty V, Krishna YM, Maqsood A, Ahmad MH, Ali M, Samuel B, Gohar A, Waheed A, Afzal MB, Ahmad RN, Maqsood S.   +12 more
europepmc   +1 more source

Synergistic Integration of Artificial Merkel Disc and Meissner Corpuscle via Dermal Papillary Structures for Mechanically Filtered Multimodal Tactile Sensing

Advanced Science, EarlyView.
A multimodal tactile sensor module that mimics the spatial arrangement and function of Merkel discs and Meissner corpuscles within the human papillary structure operates in a self‐powered manner, responding to both dynamic and static stimuli, achieving tactile perception more similar to human skin.
Jaehyeong Kim, Bohee Maeng, Seunghwan Seo, Kyoung‐Yong Chun, Chang‐Soo Han   +4 more
wiley   +1 more source

Microstructure modeling and computational micromechanics of glued metallic hollow-sphere composites. [PDF]

Arch Appl Mech
Jabs L, Zhou X, Penter L, Ihlenfeldt S, Schneider M.   +4 more
europepmc   +1 more source