Results 201 to 210 of about 22,230 (251)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Evaluation of color stability and bond strength of interim restorations fabricated by CAD/CAM and 3D printing: an in vitro study. [PDF]

BMC Oral Health
Aly YM, Fahmy MH, Sweid N.
europepmc   +1 more source

Bridged h‐BN Nanosheets Coatings: Simultaneous Shielding Atomic‐Oxygen Irradiation and Achieving Superior Friction Performance

Advanced Science, EarlyView.
ABSTRACT To confront extreme space environments, a combination of inorganic and organic coatings can provide a pathway for offering highly durable radiation resistance and anti‐friction simultaneously. Herein, a strong interfacial 3D hydrogen‐bonding network is designed to create robust hexagonal boron nitride (h‐BN) based polymer coatings with ...
Zhuoyi Li, Changning Bai, Xingkai Zhang, Yusheng Liang, Wei Wu, Dingrui Zhou, Tao Du, Chunjin Wang   +7 more
wiley   +1 more source

Mechanical properties of white matter tracts in aging assessed via anisotropic MR elastography. [PDF]

Imaging Neurosci (Camb)
Caban-Rivera DA, Williams LT, McGarry MDJ, Smith DR, Van Houten EEW, Paulsen KD, Bayly PV, Johnson CL.   +7 more
europepmc   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Analysis of the influence of nonlocal factors on the vibration of Rayleigh nonlocal nanobeams on elastic foundations. [PDF]

Sci Rep
Zhao K, Wang G, Zhou Z, Wang L.
europepmc   +1 more source

Massively parallel bead-free force spectroscopy with fluorescence. [PDF]

Sci Adv
Yasunaga AB, Riopel R, Bakker DTR, Raghu D, Yang M, Li ITS.   +5 more
europepmc   +1 more source

Integrated Experimental and Computational Analysis of SLM-Fabricated Ti6Al4V Octet-Truss Scaffolds for Bone Tissue Engineering. [PDF]

Materials (Basel)
Dogadkin D, Azamatov B, Alapati S, Alapati S, Kaliyev D, Rudenko S, Sadenova M, Dmitriev N.   +7 more
europepmc   +1 more source

Role of oxygen vacancies on the structural, electronic, optical, and photocatalytic properties of Ba₂CeMO₆ (M = Bi, Sb) double perovskites: a DFT study. [PDF]

Sci Rep
Karim MA, Saha A, Hossain MJ, Kabir MS, Faruk MO, Khatun MA, Khan MR, Roy DC.   +7 more
europepmc   +1 more source

Importance of UIV+1 Slope on Shear Force and Risk of PJK Development: Mathematical and Musculoskeletal Modeling With Clinical Confirmation. [PDF]

Global Spine J
Alavi F, Nielsen CJ, Rampersaud R, Cheung AM, Lewis S.   +4 more
europepmc   +1 more source