Results 31 to 40 of about 521,208 (302)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Finite Element Analysis of the Shear Performance of Reinforced Concrete Corbels under Different Design Codes

Buildings
This study aimed to investigate the shear performance of reinforced concrete corbels and to evaluate the accuracy and safety of the Chinese code GB 50010-2010’s triangular truss model and the American code ACI 318-19’s strut-and-tie model under various ...
Yuan Huang, Leilei Peng, Hanlin Wei
doaj   +1 more source

Performance of Shear Reinforcement against Punching Shear Loads

International Journal of Engineering and Advanced Technology, 2019
This research targets to maximize the ductility and strength of the reinforced concrete flat slabs. However, to be efficient, the shear reinforcement must be anchored well in the tension and compression zones of the slab. The test results on the slab-column connection models which provided with shear reinforcement are introduced in this study.
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Numerical Investigation of the Pull-Out and Shear Mechanical Characteristics and Support Effectiveness of Yielding Bolt in a Soft Rock Tunnel

Applied Sciences
Conventional bolts frequently fail under large deformations due to stress concentration in soft rock tunnels. In contrast, yielding bolts incorporate energy-absorbing mechanisms to sustain controlled plastic deformation.
Yan Zhu, Mingbo Chi, Yanyan Tan, Ersheng Zha, Yuwei Zhang   +4 more
doaj   +1 more source

Timoshenko Beam Model for Lateral Vibration of Liquid-Phase Microcantilever-Based Sensors [PDF]

, 2013
Dynamic-mode microcantilever-based devices are potentially well suited to biological and chemical sensing applications. However, when these applications involve liquid-phase detection, fluid-induced dissipative forces can significantly impair device ...
Beardslee, Luke A., Brand, Oliver, Dufour, Isabelle, Heinrich, Stephen M., Josse, Fabien, Nigro, Nicholas J., Schultz, Joshua A.   +6 more
core   +5 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Study on the Tensile and Shear Performances of Fully Precast Partially Composite Floor Slab Joints

Buildings
This study explored the tensile and shear characteristics of fully prefabricated partially composite floor slab joints through the design and testing of two tensile specimens, three steel–concrete specimens, and three concrete–concrete shear specimens ...
Yongsheng Zhang, Kanghui Chang, Yukun Yang, Guangchen Zhao, Yanjun Liu   +4 more
doaj   +1 more source

Shear Performance Mechanism Description Using Digital Image Correlation [PDF]

Structural Engineering International, 2018
Outstanding Paper Award en la categoria de Scientific Paper, atorgat per la International Association for Bridge and Structural Engineering (IABSE)
Alfred Strauss, Pablo Castillo, Konrad Bergmeister, Bernhard Krug, Roman Wan-Wendner, Marco Marcon, Jose Matos, Joan Ramon Casas   +7 more
openaire   +4 more sources

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source