Results 41 to 50 of about 160,905 (311)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Design and Evaluation of a Single-Span Bridge Using Ultra- High Performance Concrete;TR-529, September 2009 [PDF]
, 2009 Research presented herein describes an application of a newly developed material called Ultra-High Performance Concrete (UHPC) to a single-span bridge. The two primary objectives of this research were to develop a shear design procedure for possible code
core
BuildingsThis study aimed to investigate the shear performance of reinforced concrete corbels and to evaluate the accuracy and safety of the Chinese code GB 50010-2010’s triangular truss model and the American code ACI 318-19’s strut-and-tie model under various ...
Yuan Huang, Leilei Peng, Hanlin Wei
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A shear-stress responsive nano-container to target critically constricted arteries [PDF]
, 2014 Atherosclerosis and associated cardiovascular diseases are the world's biggest cause of mortality. During the acute case of heart attack, vasodilators are administered to open up the constricted artery and allow blood perfusion to the surrounding tissue.
Holme, Margaret Nancy
core +1 more source
Applied SciencesConventional bolts frequently fail under large deformations due to stress concentration in soft rock tunnels. In contrast, yielding bolts incorporate energy-absorbing mechanisms to sustain controlled plastic deformation.
Yan Zhu +4 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Shear capacity of reinforced concrete beams using neural network [PDF]
, 2007 NoOptimum multi-layered feed-forward neural network (NN) models using a resilient back-propagation algorithm and early stopping technique are built to predict the shear capacity of reinforced concrete deep and slender beams.
Song, J-K. +2 more
core
Shear-Enhanced Transfer Printing of Conducting Polymer Thin Films [PDF]
, 2018 Polymer conductors that are solution-processable provide an opportunity to realize low-cost organic electronics. However, coating sequential layers can be hindered by poor surface wetting or dissolution of underlying layers.
Harald Ade (1273878) +23 more
core +2 more sources
BuildingsThe purpose of this paper is to study the shear performance of reinforced concrete corbels under a synergistic change in the main stirrup inclination angle to explore the synergistic mechanism of the main reinforcement and the stirrup inclination angle ...
Hao Huang, Chengfeng Xue, Zhangdong Wang
doaj +1 more source