Results 61 to 70 of about 9,371,692 (302)

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Study on Shear Resistance of Composite Interface of Steel Truss Ceramsite Concrete and Finite Element Simulation

Buildings
This study investigates the shear behavior of steel truss ceramsite concrete composite interfaces through double-sided direct shear tests and finite element simulations.
Zaihua Zhang, Yuqing Xiao, Guohui Cao
doaj   +1 more source

Effects of shear stress on the microalgae Chaetoceros muelleri [PDF]

, 2010
The effect of shear stress on the viability of Chaetoceros muelleri was studied using a combination of a rheometer and dedicated shearing devices. Different levels of shear stress were applied by varying the shear rates and the medium viscosities. It was
Michiel H. A. Michels, Goot, A.J., van der, Michels, M.H.A., Niels-Henrik Norsker, Norsker, N.H., Atze J. van der Goot, Wijffels, R.H., René H. Wijffels   +7 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Shear viscosity and nonlinear behaviour of whole blood under large amplitude oscillatory shear [PDF]

, 2014
We investigated experimentally the rheological behavior of whole human blood subjected to large amplitude oscillatory shear under strain control to assess its nonlinear viscoelastic response.
Sousa, P.C., Carneiro, J., Vaz, R., Pinho, F.T., Oliveira, Monica, Alves, M.A., Cerejo, A.   +6 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Experiments on a barotropic rotating shear layer. Part 1. Instability and steady vortices [PDF]

, 1999
The barotropic shear layer in a rotating fluid is studied in a laboratory experiment. Through the rotation of circular sections in the base and lid of a circular tank relative to a background rotation of the entire system, a vertical layer of strong ...
Fruh, Wolf-Gerrit; id_orcid, Read, Peter L.   +1 more
core   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Review and prospects of shear test of bolted rock joints

Deep Underground Science and Engineering
Rock bolting is a critical approach in geotechnical engineering for supporting weak rocks. However, weak structural planes, such as rock joints and faults, can easily cause shear deformation of bolts, leading to large shear deformation failure.
Shulin Ren, Fan Yang, Manchao He, Yong Yuan, Zhigang Tao   +4 more
doaj   +1 more source

Shear Performance of RC Beams Reinforced by Thin Layer of Epoxy Mortar with High Strength and High Toughness

Applied Sciences
This study aims to improve the shear performance of reinforced concrete (RC) beams by utilizing the favorable tensile and shear deformation capabilities of high-strength, high-toughness epoxy mortar.
Weizhao Li, Tianhao Wen, Lingye Li, Chenggui Jing   +3 more
doaj   +1 more source