Results 161 to 170 of about 1,373,457 (385)

Engineering Decavalent, Sperm‐Binding Laminin‐IgG Hybrid Antibodies for Potent Non‐Hormonal Contraception

open access: yesAdvanced Science, EarlyView.
This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer   +8 more
wiley   +1 more source

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep

open access: yesAdvanced Science, EarlyView.
The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu   +12 more
wiley   +1 more source

Engineered Anti‐Senescence Trachea With Post‐Transplanted Regenerative Homeostasis

open access: yesAdvanced Science, EarlyView.
Bioengineered trachea undergoes post‐transplanted senescence, which is found in this study for the first time. Hebe‐ET is designed with dual anti‐senescence strategies: fiber‐film scaffold in cartilage rings for close‐packed cell interaction, and quercetin‐loaded fibrous rings for immune modulation.
Ziyin Pan   +14 more
wiley   +1 more source

Heme/NADH Mimics Co‐Decorated Allosteric Capsules for Regulating Oxygen Activation and Upregulating Intracellular Methionine Depletion

open access: yesAdvanced Science, EarlyView.
Through modifying the switchable µ‐oxo bridged FeIII‐porphyrins moiety and NADH mimics into a metal‐organic capsule, multiple responsive manners for O2 activation, chemical oxygenation and metabolic transformation have been demonstrated for upregulating intracellular methionine depletion and accumulation of methionine sulfoxide to achieve effective ...
Chunming Ma   +5 more
wiley   +1 more source

ECONOMIC ANALYSIS OF CONTROLLING LEAFY SPURGE WITH SHEEP [PDF]

open access: yes
Leafy spurge (Euphorbia esula L.), a widely established exotic, noxious, perennial weed, is a major threat to rangeland and wildland in the Upper Great Plains. Chemical, biological, and cultural control methods have limitations in their applicability and
Bangsund, Dean A.   +3 more
core   +1 more source

Incorporating economic multipliers in a bid adjustment algorithm for public food procurement decision making

open access: yesApplied Economic Perspectives and Policy, EarlyView.
Abstract We present an adjusted bid price mechanism that incorporates economic multiplier effects in public food procurement decision making. Under Input–Output model assumptions, the algorithm estimates enhanced tax revenues to state governments through multiplier effects associated with in‐state supplier purchasing.
Todd M. Schmit, Xiaoyan Liu
wiley   +1 more source

Prevalence of chlamydiae in dairy cattle herds and factors contributing to the spread of infections

open access: yesJournal of Veterinary Research
Different Chlamydia species affect cattle and contribute to economic losses. One of them, C. pecorum, is a globally endemic livestock pathogen. Despite its endemicity, prevalence data from Poland have so far been limited.
Szymańska-Czerwińska Mońika   +4 more
doaj   +1 more source

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