Results 61 to 70 of about 2,284 (213)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Conceptualisation of the SHIFT–SHARE: A New Strategic Healthcare Implementation Framework for Task Shifting, Sharing and Resource Enhancement

open access: yesGlobal Implementation Research and Applications
AbstractHealthcare systems challenged by chronic workforce shortages use task shifting and task sharing as tools to transfer certain services from providers with a high skill base to providers typically with fewer skills or qualifications. The World Health Organization’s global guidelines on task shifting advised countries to develop regulatory and ...
Shukanto Das, Liz Grant, David Weller
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Local multiplier of industrial employment: Brazilian mesoregions (2000-2010)

open access: yesBrazilian Journal of Political Economy
This paper estimates the local multiplier of manufacturing for Brazil (2000-2010). The method is based on (Moretti, 2010) and on (Moretti and Thulin, 2012), who estimated these multipliers for the U.S. and Sweden.
GUILHERME MACEDO, LEONARDO MONASTERIO
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

ANALISIS LQ DAN ANALISIS SHIFT- SHARE DALAM PEMANFAATAN EKONOMI SEKTORAL KABUPATEN MALUKU TENGAH TAHUN 2008 – 2010

open access: yesBarekeng, 2014
PDRB merupakan Indikator Ekonomi Makro yang dapat diturunkan untuk menghitung indikator-indikator penting lainnya seperti Pertumbuhan Ekonomi, PDRB Per Kapita, Pendapatan Per Kapita dan sebagainya. Selain itu, PDRB dapat digunakan untuk berbagai analisis.
Jefri Tipka
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

LA PRODUCTIVIDAD DEL SECTOR SERVICIOS EN PASTO

open access: yesTendencias, 2010
En este artículo, a través del modelo shift share, se cuantifica el aporte relativo de cada una de las ramas al crecimiento de la productividad del sector servicios en el Municipio de Pasto, durante el período 2005 – 2009, basado en datos de Cuentas ...
Martha Alejandra Santacruz
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Influência da taxa de câmbio e do dólar sobre os preços da borracha natural brasileira

open access: yesRevista Árvore, 2013
Este estudo analisou a influência da taxa de câmbio adotada pelo Brasil e do dólar sobre os preços da borracha natural em moeda brasileira, de janeiro de 2000 a dezembro de 2009. Para isso, fez-se uso do método "shift-share".
Naisy Silva Soares   +2 more
doaj   +1 more source

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