Results 81 to 90 of about 590,627 (304)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Counting digital filters [PDF]

open access: yes, 1973
Several embodiments of a counting digital filter of the non-recursive type are disclosed. In each embodiment two registers, at least one of which is a shift register, are included. The shift register received j sub x-bit data input words bit by bit.
Zohar, S.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Novel shift register eliminates logic gates and power switching circuits [PDF]

open access: yes, 1971
Register requiring two integrated circuits per stage has nominal power dissipation of 3.5 mW per stage, its use eliminates reset pulse, allowing data transfer to occur in less than 1 microsecond, and eliminates power application to both right and left ...
Cliff, R. A.
core   +1 more source

The Pagoda Sequence: a Ramble through Linear Complexity, Number Walls, D0L Sequences, Finite State Automata, and Aperiodic Tilings

open access: yes, 2009
We review the concept of the number wall as an alternative to the traditional linear complexity profile (LCP), and sketch the relationship to other topics such as linear feedback shift-register (LFSR) and context-free Lindenmayer (D0L) sequences.
Anthony K. Seda   +4 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

On a clock-controlled keystream generator and its cryptographic properties

open access: yesTongxin xuebao, 2007
A new clock-controlled keystream generator was proposed,which was composed of three shift registers: two clock-controlled linear feedback shift registers A,B,and one clock-controlling nonlinear feedback shift register C.Let l1,l2 and l3 denote the length
MA Wei-ju1, FENG Deng-guo1
doaj   +2 more sources

Novel Quantum Encryption Algorithm Based on Multiqubit Quantum Shift Register and Hill Cipher

open access: yesAdvances in High Energy Physics, 2014
Based on a quantum shift register, a novel quantum block cryptographic algorithm that can be used to encrypt classical messages is proposed. The message is encoded and decoded by using a code generated by the quantum shift register.
Rifaat Zaidan Khalaf   +1 more
doaj   +1 more source

Shift work and physical inactivity: findings from the Finnish Public Sector Study with objective working hour data

open access: yesScandinavian Journal of Work, Environment & Health, 2020
OBJECTIVES: Shift work is a risk factor for chronic diseases, and physical inactivity can have an influence on this association. We examined whether intra-individual changes in working time characteristics were associated with changes in physical ...
Wan-Ju Cheng   +5 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

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