Results 41 to 50 of about 192,353 (293)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Obfuscation of logic schemes of pseudo-random number generators based on linear and non-linear feedback shift registers

open access: yesБезопасность информационных технологий, 2021
The paper describes methods of protection against reverse engineering of logic circuits of pseudo-random number generators (PRNG) on linear and non-linear feedback shift registers.
Michael A. Ivanov   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Some remarks on FCSRs and implications for stream ciphers

open access: yesJournal of Mathematical Cryptology, 2009
Feedback with carry shift registers (FCSRs) are extensively discussed in the context of pseudorandom number generation and as building blocks for stream ciphers.
Fischer Simon   +2 more
doaj   +1 more source

Theory and application of feedback shift registers [PDF]

open access: yes, 1971
Document summarizes state-of-the-art in data processing techniques on-board spacecraft, and serves as an aid for personnel requiring tutorial knowledge of ultrareliable data processing ...
Perlman, M.
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Primitive polynomials and word oriented linear feedback shift registers

open access: yesTongxin xuebao, 2009
Through a large number of experiments, an explicit formula was proposed for the number of primitive σ-LFSRs over finite field, which generalized a known formula for the number of primitive LFSRs over finite field, and also was the extension of the number
ZENG Guang   +3 more
doaj   +2 more sources

Binary to binary coded decimal converter [PDF]

open access: yes, 1978
A binary coded input signal is converted to a binary coded decimal signal having N decades by employing N four bit shift registers. The bits of the input signal are sequentially supplied, in order, to the least significant position of the register for ...
Miller, A. J.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Deciding Irreducibility/Indecomposability of Feedback Shift Registers Is NP-Hard

open access: yesIET Information Security
Feedback shift registers (FSRs) are used as a fundamental component in electronics and confidential communication. A FSR f is said to be reducible if all the output sequences of another FSR g can also be generated by f and the FSR g costs less memory ...
Lin Wang
doaj   +1 more source

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