Results 61 to 70 of about 1,903,301 (306)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A SUMMARY OF THE LITERATURE ON SHIFT-SHARE ANALYSIS [PDF]
Shift-share analysis is a method of decomposing regional income or employment growth patterns into expected (share) and differential (shift) components. Since its inception in the 1940s, over seventy academic contributions have criticized, defended, and ...
Loveridge, Scott, Selting, Anne C.
core +1 more source
Shift-Share Analysis: Review of Spatial Versions
Regionalistica, 2022 The article presents the genesis of spatial shift-share analysis. The author focuses on the links of spatial versions of shift-share analysis with the classical one, which is not just a starting point for them from a historical point of view, but retains the status of their constituent element.
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Europäische Metropolregionen in Deutschland – eine regionalökonomische Evaluation
Raumforschung und Raumordnung, 2010 For more than ten years the concept of European Metropolitan Regions is fixed in the German regional planning system. This article uses the shift-share-technique to assess the economic performance of the eleven German metropolitan areas based on a ...
Karsten M. Rusche, Christian A. Oberst
doaj +1 more source
An Application of the Shift Share Analysis for Transformation of the Agricultural Sector in Economic Areas at South East Sulawesi [PDF]
, 2015 Agriculture sector is still dominan in Product Domestic Regional Bruto (PDRB) at South East Sulawesi Province. Shift share Analysis is one of analysis tools that can be used to analyze shift and share of overall of sectors of PDRB.
Abidin, Z. -. (Zainal)
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Regional and structural factors in Swedish regional growth during the 1990s
Cybergeo, 2006 Based on the Swedish Standard Industrial Classification and individual longitudinal data, by using the shift-share analysis method, Swedish regional employment growth during the 1990s has been decomposed into two components—growth due to an endogenous ...
Li Wenjuan
doaj +1 more source
Employment growth in Ceara: a shift-share analysis (2000-2005) [PDF]
Between 2000 and 2005, formal employment grew by 33.15% in Ceara (Brazil). Hence, the main objective of this paper was to analyze which municipalities and sectors contributed the most to such growth through a shift-share analysis of employment.
Feitosa Lopes, Daniel Alisson +1 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source