Results 71 to 80 of about 1,903,301 (306)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Shift–share Analysis of manufacturing as a measuring instrument for Human Resource Management
SA Journal of Human Resource Management, 2009 Shift-share analysis of employment as a measuring instrument for human resource management is proposed by this study. The results obtained through this technique can assist human resource management on the macro-level in making informed and strategic ...
Ewert Philippus Kleynhans
doaj +1 more source
Evolution of Regional Disparities in Romania – A Shift-share Analysis [PDF]
The paper aims to assess the evolution of the development disparities (output, employment, overall and by sectors) in the regions and counties of Romania.
Mihaela-Nona Chilian
core
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
A Dynamic Shift-Share Analysis of Economic Growth in West Virginia
Journal of Rural and Community Development, 2012 A regional economy consists of industries with a variety of economic potentials. A growth or decline in any of these sectors affects the overall growth of the economy.
Saman Janaranjana Herath Bandara +2 more
doaj
VALUE-ADDED WHEAT PRODUCT TRADE [PDF]
This study evaluated international trade of value-added wheat products. Analyzed were market size and growth rate by country for each product group. Shift share analysis was used to examine changes in market shares for each value-added wheat product ...
Onnen, Jennifer M., Wilson, William W.
core +1 more source
Transformasi Struktur Ekonomi dan Sektor Unggulan di Kabupaten Buleleng Periode 2008-2013 [PDF]
, 2016 The impact of development of a region, such as the changes in what sectors increases or decreases, the knowledge of which is important in the development of a region.
Suyana Utama, I Made +1 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The evolution of the employment in the European Union. A stochastic shift and share approach [PDF]
The employment is a main economic variable whose evolution has shown different dynamics within the European Union. Recent papers have recovered the significance of the sectoral factors in the explanation of the regional growth.
López Menéndez, Ana Jesús +1 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source