Results 121 to 130 of about 1,432,960 (308)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Compensating differentials for nurses [PDF]
When entering the job market registered nurses (RNs) face job alternatives with differences in wages and other job attributes. Previous studies of the nursing labor market have shown large earnings differences between similar hospital and non-hospital ...
Sæther, Erik Magnus
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2013 Aline Silva-Costa,1,2 Frida Marina Fischer,1 Rosane Harter Griep,2 Lúcia Rotenberg2 1School of Public Health, University of São Paulo, São Paulo, Brazil; 2Laboratory of Health, Environment and Education, Oswaldo Cruz Institute ...
Silva Costa A +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The shift team formation problem in multi-shift manufacturing operations
This paper addresses the problem of assigning operators to teams that work in single-, two-, or three-day shift systems. The problem was motivated by, and illustrated with a case situation encountered in Dutch manufacturing industry.
Suresh, Nallan C., Slomp, Jannes
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Evaluation of Sleep, Quality of Life, and Nutritional Status of Shift and Non-Shift Male Workers [PDF]
Objective: Work performed outside of standard working hours is considered shift work. Shift work is beneficial to organizations, but individuals working in these organizations are at risk of various health problems, especially sleep disorders. The aim of
Dide Kılıçalp Kılınç +1 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source