Results 171 to 180 of about 1,432,960 (308)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Associations of eating duration and shift work with accelerated biological aging among U.S. workers. [PDF]

J Nutr Health Aging
Ren X, Li J, Chen L.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Shift work, genetic risk, and incident gout: a prospective cohort study in the UK Biobank. [PDF]

Arch Public Health
Wu C, Zhang H, Xia J, Peng B, Chen J, Wang M, Wu S, Jiang Z, Ji S, Yang Y, You Y, Kwan HY, Sun Z, Zhao X, Liu Y.   +14 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Shift work and eating behavior

, 2015
1 ethesis (483 pages) :illustrations (some colour)Includes bibliographical references (pages 213-259)Many health disorders associated with shiftwork may result from alterations in eating behaviour. This thesis hypothesises that mood (fatigue and stress),
Heath, Georgina,
core  

Shift work and the risk of incident hospital-treated infections: quantifying the role of lifestyle factors. [PDF]

BMC Infect Dis
Zhou Y, Chen Y, Xu M, Yan H, Yin X.
europepmc   +1 more source

The Problems of Shift Work

Journal of the Royal College of Physicians of London, 1969
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effects of Shift Work Type on Sleep Quality and Cortisol Regulation Among Nurses: A Prospective Observational Study. [PDF]

Int J Environ Res Public Health
Dujmić Ž, Mikšić Š, Mudri Ž, Barišić M, Barać I, Vujanić J, Čebohin M, Gvozdanović Z, Pačarić S, Grnja V, Samardžić J, Mihaljević I, Farčić N.   +12 more
europepmc   +1 more source