Results 131 to 140 of about 624,139 (310)
Latin America and the Shifting Sands of Global Power: Introduction
, 2020 Latin America occupies an increasingly prominent position within the global political, economic and cultural consciousness, with intra-regional governance structures and multilateral processes now a key topic of interest to foreign policy and ...
Burges, Sean
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Capital structure and international debt shifting [PDF]
This paper presents a model of a multinational firm's optimal debt policy that incorporates international taxation factors. The model yields the prediction that a multinational firm's indebtedness in a country depends on a weighted average of national ...
Luc Laeven +2 more
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Autonomous control of a shape-shifting robot in urban terrain
, 2007 An autonomous control system is developed for a shape-shifting robot "AMOEBA-I" to be possibly used in the urban terrain. Based on the sensors including GPS, electronic compass, inclinometer and encoder, the autonomous motions of AMOEBA-I are ...
Liu JG(刘金国) +7 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Style-Shifting in Public New Perspectives on Stylistic Variation
Language acts are acts of identity, and linguistic variation reflects the multifaceted construction of verbal alternatives for transmitting social meaning, where style-shifting represents our ability to take up different social positions due to its ...
Hernández-Campoy, Juan Manuel. +1 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A dynamic shape-shifting method for a transformable tracked robot
, 2010 The reconfiguration is always an important issue for a transformable robot, Amoeba-II. In the shape-shifting process, the friction between the tracks and the ground generally makes it difficult for the robot to finish the transformation and it also ...
Ma SG(马书根) +4 more
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