Results 111 to 120 of about 4,742,454 (347)
How Emotions Influence Cognitive Control: A Within-Subject Investigation
Behavioral SciencesThis study examined how negative emotions influence three core components of cognitive control, inhibition, updating, and shifting, as assessed through a Go/No-Go, 2-back, and set-switching task, respectively.
Tristan Feutren, Ludovic Fabre
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The extent and measurement of VCR time shifting : a thesis presented in partial fulfilment of the requirements for the degree of Master of Business Studies in Marketing at Massey University [PDF]
, 1997 The validity and accuracy of television programme ratings are critical to media planners and broadcasters alike. Media planners use ratings to select programmes that will satisfy certain reach and frequency objectives, which in turn contribute to an ...
Turner, Penelope Jane
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
On Context Shifters and Compositionality in Natural Languages [PDF]
, 2018 My modest aim in this paper is to prove certain relations between some type of hyper-intensional operators, namely context shifting operators, and compositionality in natural languages. Various authors (e.g.
Briciu, Adrian
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Shifting Innovation to Users via Toolkits
Management Sciences, 2002 In the traditional new product development process, manufacturers first explore user needs and then develop responsive products. Developing an accurate understanding of a user need is not simple or fast or cheap, however.
E. Hippel, R. Katz
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A Noise-Shifting Differential Colpitts VCO [PDF]
, 2002 A novel noise-shifting differential Colpitts VCO is presented. It uses current switching to lower phase noise by cyclostationary noise alignment and improve the start-up condition.
Aparicio, Roberto, Hajimiri, Ali
core