Results 91 to 100 of about 3,389,884 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Risk Shifting, Unemployment Insurance, and Layoffs [PDF]
This paper develops an analysis of labor markets in which the use of layoffs to effect employment separations does not imply that markets fail to clear or that the amount of employment is suboptimal relative to current perceptions.
Herschel I. Grossman
core
Shifting attention to accuracy can reduce misinformation online
Nature, 2021 Gordon Pennycook +5 more
semanticscholar +1 more source
Shifting the optimal stiffness for cell migration
Nature Communications, 2017 Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal.
Benjamin L. Bangasser +10 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Shifting horizons in local and regional development
Transitions in Regional Economic Development, 2017 Shifting horizons in local and regional development. Regional Studies. This paper aims, first, to trace the evolution of thinking about local and regional development in order to situate current debates in their sometimes neglected historical context and,
A. Pike +2 more
semanticscholar +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Economic models of shifting cultivation: a review [PDF]
This chapter reviews farm-level economic models of shifting cultivation and those of deforestation and soil conservation related to shifting cultivation.
Yoshito Takasaki
core
Processing time not modality dominates shift costs in the modality-shifting effect [PDF]
, 2019 Shifting attention between visual and auditory targets is associated with reaction time costs, known as the modality-shifting effect. The type of modality shifted from, e.g., auditory or visual is suggested to have an effect on the degree of cost ...
Roebuck, H., Bourke, P, Guo, K
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source