Results 151 to 160 of about 14,812 (194)

Advancing Medical Diagnostics: Rapid, Label-Free Detection and Differentiation of Shiga Toxin Variants in Human Serum Using a Cost-Effective PCA-Assisted SERS Platform. [PDF]

ACS Appl Mater Interfaces
Milano A, D'Avino A, Marchesano V, Sagnelli D, Rippa M, Guilcapi B, Zhou L, Varrone E, Rossi G, Brigotti M, Ardissino G, Morabito S, Petti L.   +12 more
europepmc   +1 more source

Detonating a "time bomb": how enteric infection stress triggers prophage induction in commensal microbiota and exacerbates disease progression. [PDF]

Front Microbiol
Yang L, Xu Y, Wang X.
europepmc   +1 more source

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Affinity purification of Shiga-like toxin I and Shiga-like toxin II

Journal of Microbiological Methods, 1998
Abstract A facile method is described for affinity purifying Shiga-like toxin I (verotoxin 1) or Shiga-like toxin II (verotoxin 2) from cell-free Escherichia coli culture supernatant solutions using immobilized synthetic analogs of the digalactoside [αGal(1,4)βGal] host cell receptor for these toxins.
George L Mulvey, Glen D Armstrong
exaly   +2 more sources

Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells

Microbes and Infection, 2001
Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.
Roy Robins-Browne, E V O'Loughlin
exaly   +3 more sources

Inhibition Of Shiga-Like Toxins By Brefeldin A

Journal of Infectious Diseases, 1995
The effects of Shiga-like toxins on the morphology and protein synthetic capability of HeLa cells in tissue culture could be prevented by brefeldin A, an inhibitor of certain intracellular Golgi functions. Brefeldin A was without effect on the binding of Shiga-like toxin to cells.
S T, Donta, T K, Tomicic, A, Donohue-Rolfe   +2 more
openaire   +2 more sources

The use of Shiga-like toxin 1 in cancer therapy

Critical Reviews in Oncology/Hematology, 2001
The ribosome-inactivating protein, Shiga-like toxin-1 (SLT-1, SLT-I, Verotoxin 1, VT1) targets cells that express the glycolipid globotriaosylceramide (CD77) on their surface. The frequent occurrence of SLT-1 receptors on tumor cells derived from patients with hematological cancers (follicular lymphoma, multiple myeloma, chronic lymphocytic leukemia ...
Jean Gariépy
exaly   +3 more sources

DNA probes for Shiga-like toxins I and II and for toxin-converting bacteriophages

Journal of Clinical Microbiology, 1988
A set of DNA probes has been developed to study the genes for Shiga-like toxins (SLT) and the bacteriophage from which these toxin genes were isolated. Under stringent conditions of hybridization (80 to 90% homology), these probes detect strains containing (i) SLT I-related genes, (ii) SLT II-related genes, (iii) phage sequences from the SLT I ...
J W, Newland, R J, Neill
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Effects of Human Intravenous Immune Globulin on Diarrhea Caused by Shiga‐Like Toxin I and Shiga‐Like Toxin II in Infant Rabbits

Microbiology and Immunology, 1992
AbstractShiga toxin and the related Shiga‐like toxins (SLT), produced by Escherichia coli, can cause hemorrhagic colitis and hemolytic uremic syndrome (HUS). Human intravenous immune globulin (HIVIg) blocks the cytotoxicity of some SLTs in vitro. To examine the ability of HIVIg to modify disease caused by Shiga‐like toxin I or Shiga‐like toxin II (SLT ...
P L, Havens, W M, Dunne, E M, Burd
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Effect of verocytotoxins (Shiga-like toxins) on human neutrophils in vitro

Pediatric Nephrology, 2005
Neutrophil activation occurs in diarrhoea-associated HUS and correlates with disease severity, implying a role in pathogenesis. Verocytotoxin (Shiga-like toxin) has been shown to stimulate endothelium to release chemokines and express leukocyte adhesion molecules that would lead to indirect neutrophil-endothelial interaction.
Julie U, Holle, Julie M, Williams, Lorraine, Harper, Caroline O S, Savage, C Mark, Taylor   +4 more
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Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands

Nature, 2000
The diseases caused by Shiga and cholera toxins account for the loss of millions of lives each year. Both belong to the clinically significant subset of bacterial AB5 toxins consisting of an enzymatically active A subunit that gains entry to susceptible mammalian cells after oligosaccharide recognition by the B5 homopentamer. Therapies might target the
P I, Kitov, J M, Sadowska, G, Mulvey, G D, Armstrong, H, Ling, N S, Pannu, R J, Read, D R, Bundle   +7 more
openaire   +2 more sources