Results 161 to 170 of about 14,812 (194)
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Mutations affecting the activity of the Shiga-like toxin I A-chain
Biochemistry, 1992Like ricin, Escherichia coli Shiga-like toxin I (SLT-I) inactivates eukaryotic ribosomes by catalytically depurinating adenosine 4324 in 28S rRNA. Although the primary structure of the enzymatic portion of the molecule (Slt-IA) is known to contain regions of significant homology to the ricin A chain (RTA), and although certain residues have been ...
R L, Deresiewicz +3 more
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Shiga-Like Toxins as Targeted Anticancer Agents
2002A large number of structurally related protein toxins are derived from bacterial and plant sources. They target specific cell types by virtue of their receptor-binding domains that typically recognize glycolipids or glycoproteins. Some of these toxins, such as ricin and abrin, are ribosome-inactivating proteins (or RIPs) defining them as cytotoxic ...
Paul LaPointe, Jean Gariépy
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Hemolytic uremic syndrome induced by lipopolysaccharide and Shiga-like toxin
Pediatric Nephrology, 2004Induction of experimental hemolytic uremic syndrome (HUS) by simply administering Shiga-like toxin (Stx) to rodents has not yet been successful. Attention has been paid to the role of lipopolysaccharide (LPS) in the pathogenesis of HUS. In this study, we showed successful induction of an experimental HUS in LPS responder mice by administering Stx ...
Masahiro, Ikeda +2 more
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2011
Ricin, Shiga-like toxin 1 (Stx1) and Shiga-like toxin 2 (Stx2) are ribosome inactivating proteins (RIPs) that catalytically remove an adenine residue from the highly conserved α-sarcin/ricin loop (SRL) in the large ribosomal subunit, inhibiting the translocation step of protein synthesis.
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Ricin, Shiga-like toxin 1 (Stx1) and Shiga-like toxin 2 (Stx2) are ribosome inactivating proteins (RIPs) that catalytically remove an adenine residue from the highly conserved α-sarcin/ricin loop (SRL) in the large ribosomal subunit, inhibiting the translocation step of protein synthesis.
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Mode of Action of Shiga and Shiga-Like Toxins
1990Enterohemorrhagic Escherichia coli 0157:H7 and other serotypes produce at least two distinct cytotoxins that affect Vero cells (Vero toxins).9,14,15,17 Both Vero toxins have been purified to homogeneity and the properties of the purified toxins have been examined extensively.9,17 One of them was found to be identical to Shiga toxin in molecular ...
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Shiga‐like toxin I is a polynucleotide:adenosine glycosidase
Molecular Microbiology, 1998L, Barbieri +5 more
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Structure-function analyses of Shiga toxin and the Shiga-like toxins
Microbial Pathogenesis, 1990openaire +2 more sources