Journal of Clinical Microbiology, 2002 We recently described a novel megaplasmid-encoded adhesin produced by certain Shiga toxigenic Escherichia coli (STEC) strains that lack the locus for enterocyte effacement (LEE) pathogenicity island.
Adrienne W. Paton, James C. Paton
openalex +2 more sources
Characterization of Bacteriophages Targeting Non-O157 Shiga Toxigenic Escherichia coli
Journal of Food Protection, 2018 Non-O157 Shiga toxigenic Escherichia coli (STEC) are an important group of foodborne pathogens, implicated in several outbreaks and recalls in the past 2 decades. It is therefore crucial to devise effective control strategies against these pathogens. Bacteriophages present an attractive alternative to conventional pathogen control methods in the food ...
Pushpinder Kaur Litt +2 more
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Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli [PDF]
Microbial Pathogenesis, 2011 Subtilase cytotoxin (SubAB) is an AB(5) type toxin produced by a subset of Shiga-toxigenic Escherichia coli. The A subunit is a subtilase-like serine protease and cleaves an endoplasmic reticulum chaperone BiP. The B subunit binds to a receptor on the cell surface. Although SubAB is lethal for mice, the cause of death is not clear.
Kinnosuke Yahiro +9 more
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Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues [PDF]
Cell Death Discovery, 2018 AbstractShiga toxigenic Escherichia coli (STEC) are responsible for a worldwide foodborne disease, which is characterized by severe bloody diarrhea and hemolytic uremic syndrome (HUS). Subtilase cytotoxin (SubAB) is a novel AB5 toxin, which is produced by Locus for Enterocyte Effacement (LEE)-negative STEC.
Kimitoshi Ichimura +11 more
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GeneSippr: a rapid whole-genome approach for the identification and characterization of foodborne pathogens such as priority Shiga toxigenic Escherichia coli. [PDF]
PLoS One, 2015 The timely identification and characterization of foodborne bacteria for risk assessment purposes is a key operation in outbreak investigations. Current methods require several days and/or provide low-resolution characterization. Here we describe a whole-
Lambert D +4 more
europepmc +2 more sources
Attachment of Shiga Toxigenic Escherichia coli to Beef Muscle and Adipose Tissue
Journal of Food Protection, 2006 Shiga toxigenic Escherichia coli (STEC) serotypes are important foodborne pathogens that cause gastrointestinal disease worldwide. An understanding of how STEC strains attach to surfaces may provide insight into the potential persistence of and contamination with STEC in food environments. The initial attachment of a selection of STEC serotypes to beef
Rivas, L, Dykes, GA, Fegan, N
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Shiga Toxigenic and Atypical EnteropathogenicEscherichia coliin the Feces and Carcasses of Slaughtered Pigs [PDF]
Foodborne Pathogens and Disease, 2012 Escherichia coli is a pathogen of major importance in swine and public health. To determine the prevalence of Shiga toxigenic E. coli (STEC) and enteropathogenic E. coli (EPEC), samples were collected from the feces and carcasses of swines. In total, 441 samples were collected in four samplings, of which 141 samples tested positive for either the stx1,
Borges, Clarissa Araujo +6 more
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Phage Predation Shapes the Population Structure of Shiga-Toxigenic Escherichia coli O157:H7 in the UK: An Evolutionary Perspective. [PDF]
Front Genet, 2019 Bacterial–host interactions are non-linear and actually threefold, involving significant selection through predatory lytic bacteriophages in the host environment.
Cowley LA +3 more
europepmc +2 more sources
Subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli induces stress granule formation. [PDF]
Cell Microbiol, 2016 Subtilase cytotoxin (SubAB) is mainly produced by locus of enterocyte effacement (LEE)‐negative strains of Shiga‐toxigenic Escherichia coli (STEC). SubAB cleaves an endoplasmic reticulum (ER) chaperone, BiP/Grp78, leading to induction of ER stress.
Tsutsuki H +9 more
europepmc +2 more sources
Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival. [PDF]
Sci Rep, 2020 Yahiro K +7 more
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