Results 101 to 110 of about 29,285 (250)

Structure-Activity Relationship Studies of Retro-1 Analogues Against Shiga Toxin

, 2020
The Retro-1 molecule was identified in a high-throughput screening as an inhibitor of ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus.
Valérie, Pons, David-Alexandre, Buisson, Jean-Christophe, Cintrat, Daniel, Gillet, Lilia, Ait Ouarab, Lucie, Caramelle, Aurélien, Michau, Julien, Barbier, Hajer, Abdelkafi, Flora, Ngadjeua, Alexandra, Clerget   +10 more
core   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Multiplex PCR detection of stx1, stx2 and eaeA genes in Escherichia coli isolated from lambs in ChaharmahalvaBakhtiari, Iran

Biological Journal of Microorganism, 2013
Introduction: Pathogens can be transmitted to the humans through the consumption of contaminated meat and thus causing disease. Shiga-toxin-producing Escherichia coli can cause mild watery diarrhea to more serious complications of hemorrhagic colitis ...
Marzieh Tadi Beni, Vida Najafzadeh, Hossein Kaboli Boroujeni, Naser Khosravi, Hassan Momtaz, Hossein Tahmasby, Samaneh Mehrabiyan, Farnoush Ansari   +7 more
doaj  

Molecular detection and antibiogram of Shiga toxin-producing Escherichia coli (STEC) from raw milk in and around Bahir Dar town dairy farms, Ethiopia

Heliyon
Illnesses associated with consuming infected milk and milk products are a widespread problem in low and middle-income countries. Shiga toxin-producing Escherichia coli (STEC) is a bacterium commonly found in raw milk and causes foodborne diseases ranging
Fanuel Bizuayehu Yihunie, Mequanint Addisu Belete, Gizachew Fentahun, Teshager Dubie   +3 more
doaj   +1 more source

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks-0

, 2011
Copyright information:Taken from "Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks"http://www.biomedcentral.com/1471-2180/7/109BMC Microbiology 2007;7():109-109.Published online 4 Dec 2007PMCID:PMC2211750.
Larry D Farrell (66913), Peter P Sheridan (27773), James E Lee (66909), Junelina Reed (66910), Malcolm S Shields (66911), Kathleen M Spiegel (66912)   +5 more
core   +1 more source

Shiga Toxins: Intracellular Trafficking to the ER Leading to Activation of Host Cell Stress Responses

Toxins, 2010
Despite efforts to improve hygenic conditions and regulate food and drinking water safety, the enteric pathogens, Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae serotype 1 remain major public health concerns due to widespread ...
Moo-Seung Lee, Rama P. Cherla, Vernon L. Tesh   +2 more
doaj   +1 more source

The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL‐8‐Dependent VEGF Regulation: An In Vitro Study

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp inflammation triggers immune responses involving macrophages and dental pulp stem cells (DPSCs), which interact to regulate angiogenesis essential for tissue repair. M1 pro‐inflammatory macrophages predominate early in pulpitis, and clarifying their angiogenic role is vital in identifying inflammatory regenerative ...
Dineshi Sewvandi Thalakiriyawa, Mohamad Koohi‐Moghadam, Mingxin Hu, Hong Wang, Colman McGrath, Waruna Lakmal Dissanayaka   +5 more
wiley   +1 more source

Extracellular vesicles in Shiga toxin-mediated disease [PDF]

, 2021
Extracellular vesicles are released during infectious, inflammatory and prothrombotic conditions. These are membrane-derived vesicles shed by cells during activation, senescence and/or apoptosis.
Willysson, Annie
core  

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source