Results 101 to 110 of about 21,994 (199)

Alcohol‐Induced Early‐Stage Liver Injury Contributes to Increases in Voluntary Alcohol Intake and Cognitive Deficits in Mice

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
While the liver–brain axis is well‐characterized in alcohol‐related disorders, the impact of alcohol‐associated liver disease (ALD) on alcohol use disorder (AUD)‐related behaviors remains unclear. This study investigated the effects of early‐stage ALD on alcohol consummatory behavior and cognitive function in C57BL/6 mice. Early ALD induced a transient
Samantha G. Skinner, Eliana G. Aleman, Julio Rivera, Nikhila Kalapatapu, Dhruv Kantilal, Daryl L. Davies, Liana Asatryan   +6 more
wiley   +1 more source

Flecainide binding dynamics in voltage‐gated sodium channels: A comparative isoform analysis of the state‐dependent block

British Journal of Pharmacology, Volume 183, Issue 15, Page 4145-4162, August 2026.
Background and Purpose Local anaesthetics and class I anti‐arrhythmic drugs block voltage‐gated Na+ channels, but the molecular basis for the isoform differences in drug sensitivity remains unclear. Understanding these mechanisms is essential for optimizing therapeutic efficacy and safety.
Tatsuo Munakata, Etsuko Kumada, Nao Katayama, Hiroki Nakagawa, Akihiko Sunami   +4 more
wiley   +1 more source

The Natural Quassinoid Brusatol Enhances Venetoclax Efficacy and Overcomes Resistance in Myeloid Leukemias

Cancer Science, Volume 117, Issue 8, Page 2274-2288, August 2026.
Schematic illustration of the mechanisms by which the natural quassinoid brusatol induces apoptosis in myeloid leukemias and enhances venetoclax efficacy via p53‐dependent apoptosis and mitochondrial dysfunction. ABSTRACT While venetoclax‐based combinations have shown promising results in acute myeloid leukemia (AML), the remission duration is ...
Shin‐ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Ken Suzaki, Susumu Goyama, Chiyoko Kato, Eiji Sakashita, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda   +11 more
wiley   +1 more source

Shiga Toxin [PDF]

, 2020
openaire   +1 more source

Cellular signaling pathway of Shiga toxin-induced ATP release. [PDF]

Front Cell Infect Microbiol
Johansson K, Arvidsson I, Wendler M, Kristoffersson AC, Karpman D.   +4 more
europepmc   +1 more source

Protection of Mice Orally Infected With Shiga Toxin-Producing <i>Citrobacter rodentium</i> Treated With Nanobody Multimer. [PDF]

Open Forum Infect Dis
Sheoran A, Martinot AJ, Robinson SR, Fu A, Martone C, Dayao D, Shoemaker CB, Tzipori S.   +7 more
europepmc   +1 more source

Shiga toxin increases intestinal transit to displace resident microbes and facilitate pathogen colonization. [PDF]

PLoS Pathog
Odem MA, Simbassa SB, Alvarez CF, Jeilu O, Simar SR, Bosserman R, Dutta S, Galdamez W, Ayele H, Hanson BM, Proctor DM, Krachler AM.   +11 more
europepmc   +1 more source

Factors Governing the Cross-Species Virulence of Shiga Toxin-Producing <i>Escherichia coli</i>. [PDF]

Pathogens
Hart P, Bowitch A, Mellmann A, Ferkey DM, Koudelka GB.   +4 more
europepmc   +1 more source

Click Detect: A Rapid and Sensitive Assay for Shiga Toxin 2 Detection. [PDF]

Biosensors (Basel)
Thomas BM, Webb EL, Yan KL, Fernandez AM, Chen Z.   +4 more
europepmc   +1 more source

Inter-society consensus on the management of acute bloody diarrhea and shiga toxin-producing Escherichia coli infection in the molecular microbiology era. [PDF]

Ital J Pediatr
Ardissino G, Agostiniani R, Benatti SV, Bonardi S, Brasca M, Brigotti M, Callegaro A, Centrone F, Chironna M, Clerici P, Daprai L, Dato L, Debertolis G, Decastelli L, Decembrino L, Nicola L, Mauro GD, Folli F, Gabrielli L, Gazzola A, La Porta E, Losio MN, Lo Vecchio A, Luini M, Magistrali CF, Mancuso MC, Marcantoni C, Morabito S, Nicolini G, Norsa L, Pasini A, Picozzi C, Principi N, Romano C, Ruzza ML, Zampogna S.   +35 more
europepmc   +1 more source