Results 91 to 100 of about 21,994 (199)

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Shiga Toxin Profiles of Poultry-origin Escherichia coli Isolates with Low Levels of Antimicrobial Resistance to the Clinical and Laboratory Standard Institute-recommended Antibiotics for Surveillance in Human Beings

Indian Journal of Public Health
Background: Escherichia coli are the reservoirs of antimicrobial resistance (AMR) genes. Shiga toxin-producing E. coli of animal origin can cause severe life-threatening infections in man.
Maansi Soodan, Kavita Rana, Ashok Kumar Panda, Krishanender Dinesh, Rajesh Kumar, Rajesh Kumar Vaid, Varun Sankhyan, Sidharath Dev Thakur   +7 more
doaj   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, Volume 13, Issue 44, 7 August 2026.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Editorial: Shiga Toxin-Converting Bacteriophages [PDF]

Frontiers in Microbiology, 2021
Grzegorz Węgrzyn, Muniesa, Maite
openaire   +3 more sources

RIOK2 Promotes Clear Cell Renal Cell Carcinoma Progression Through Cell Cycle Regulation

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of kidney cancer and is frequently associated with poor clinical outcomes. Ribosome biogenesis, which is upregulated in many malignancies, plays a key role in tumor proliferation.
Hiroyuki Shikuma, Keisuke Goto, Ayako Shimo, Tomoya Hatayama, Kazuma Yukihiro, Kyosuke Iwane, Ryoken Yamanaka, Ryo Tasaka, Yuki Kohada, Kenshiro Takemoto, Kohei Kobatake, Yohei Sekino, Hiroyuki Kitano, Akihiro Goriki, Keisuke Hieda, Osamu Kaminuma, Nobuyuki Hinata   +16 more
wiley   +1 more source

Effect of Porphyromonas gingivalis Infection on PGC‐1α in Skeletal Muscle After Endurance Training In Vivo

Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.
ABSTRACT Objectives It is well known that Porphyromonas gingivalis, a major pathogen in periodontitis, causes systemic diseases. This study investigated the expression of PGC‐1α (the most important factor in muscle mitochondria synthesis) following endurance training to clarify the relationship between P.
Kairi Hayashi, Yasuo Takeuchi, Hiroaki Kobayashi, Gen Tanabe, Hiroshi Churei, Toshiaki Ueno, Kenji Fueki   +6 more
wiley   +1 more source

Shiga Toxin Genes Detected in Fecal Samples of Illinois Finisher Pigs

Bacteria
(1) Background: Pigs can be another host of Shiga toxin-producing E. coli (STEC), suggesting that pork products could be a potential risk to public health. A USDA National Animal Health Monitoring System (NAHMS) study revealed that Shiga toxin genes were
Kathryn L. Lauder, Shafiullah M. Parvej, Yiyang Shen, Chongyang Zhang, Jehadi Osei-Bonsu, James F. Lowe, Weiping Zhang   +6 more
doaj   +1 more source

A Prospective Observational Study of Anamorelin During Chemoimmunotherapy in Non‐Small Cell Lung Cancer With Cachexia (SPIRAL‐ANA)

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The prognosis of patients with advanced non‐small cell lung cancer (NSCLC) complicated by cancer cachexia remains poor. Anamorelin, a ghrelin receptor agonist, has been approved only in Japan for the treatment of cancer cachexia.
Kenji Morimoto, Junji Uchino, Makoto Hibino, Yuki Takeyasu, Ken Yamamoto, Yoshie Morimoto, Yusuke Chihara, Takayuki Nakano, Hiroyasu Kaneda, Shunya Tanaka, Shinsuke Ogusu, Yasuhiro Goto, Takashi Nomizo, Takayo Ota, Hiroaki Tsukamoto, Yoshizumi Takemura, Katsumi Nakatomi, Hayato Koba, Kohei Yoshimine, Takayuki Shimose, Tadaaki Yamada, Koichi Takayama   +21 more
wiley   +1 more source

Optimization of Dual‐Bacteriophage Magnetic Nanoprobe for the Detection of Staphylococcus aureus and Pseudomonas aeruginosa

Macromolecular Bioscience, Volume 26, Issue 8, August 2026.
The optimal densities of two bacteriophages on magnetic nanoparticles are determined in order to make magnetic nanoprobes. These nanoprobes can bind bacteria in 10 min and be quickly retrieved from aqueous samples for later analysis. The nanoprobes are capable of capturing Staphylococcus aureus and Pseudomonas aeruginosa with concentrations as low as ...
Jun‐Ping Zhang, Hsin‐Yi Lin
wiley   +1 more source

Efficacy of Adjuvant Interferon‐β Versus Observation for Resected Nail Apparatus Melanoma: A Multicenter Retrospective Study

The Journal of Dermatology, Volume 53, Issue 8, Page 1124-1132, August 2026.
ABSTRACT Nail apparatus melanoma (NAM) is a biologically and clinically distinct subtype of melanoma; however, the efficacy of adjuvant interferon (IFN) therapy in this population remains unclear. We conducted a multicenter retrospective study to compare adjuvant IFN‐β (adj‐IFN) with observation (OBS) in patients with resected stage IIB, IIC, or III ...
Takaya Komori, Eiji Nakano, Yukiko Kiniwa, Shoichiro Mori, Sotaro Yamamoto, Hiroshi Kato, Shusuke Yoshikawa, Koji Yoshino, Megumi Aoki, Tatsuya Takenouchi, Takuya Maeda, Keijun Yoshino, Shuichi Ohe, Kenta Nakama, Hideyuki Ishikawa, Yoshiyuki Nakamura, Toshihiro Takai, Takamichi Ito, Hiroshi Kitagawa, Hiraku Kokubu, Naohito Hatta, Takeru Funakoshi, Toshihiko Hoashi, Takayuki Suyama, Susumu Fujiwara, Mamiko Masuzawa, Hiroshi Uchi, Takuya Miyagawa, Soichiro Kado, Yuki Yamamoto, Jun Asai, Junji Kato, Taku Maeda, Natsuki Baba, Yukihiko Kato, Kohei Oashi, Takeo Maekawa, Shunichi Jinnai, Aya Nishizawa, Ko Kagoyama, Atsushi Otsuka, Katsuhiko Nishihara, Dai Ogata, Kenjiro Namikawa, Yasuhiro Nakamura, Shigeto Matsushita   +45 more
wiley   +1 more source