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Shiga Toxin-Producing <i>Escherichia coli</i> (STEC) in Developing Countries: A 10-Year Review with Global Perspective. [PDF]

Microorganisms
Nemati A, Dadvar A, Eppinger M, Karimpour Z, Saberi Kakhki S, Sabeti Moghaddam Sabzevar A, Badouei MA, Gigliucci F, Santos LFD, Nakamura K, Javidi H, Hafiz M.   +11 more
europepmc   +1 more source

Shiga toxin-producing Escherichia coli plasmid diversity reveals virulence potential and control opportunities in animal hosts. [PDF]

Sci Rep
Nemati A, Askari Badouei M, Hashemitabar G, Hafiz M.   +3 more
europepmc   +1 more source

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Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells

Microbes and Infection, 2001
Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.
Roy Robins-Browne, E V O'Loughlin
exaly   +3 more sources

PREPARATION AND PROPERTIES OF SHIGA TOXIN AND TOXOID [PDF]

Journal of Experimental Medicine, 1946
1. Shigella dysenteriae (Shiga) can, under the proper cultural conditions, produce a soluble toxin which is independent of the specific somatic polysaccharide antigen. A method is described for the rapid production of this toxin by an avirulent R variant of this organism. 2.
René J Dubos
exaly   +4 more sources

Shiga toxins

Toxicon, 2012
Shiga toxins are virulence factors produced by the bacteria Shigella dysenteriae and certain strains of Escherichia coli. There is currently no available treatment for disease caused by these toxin-producing bacteria, and understanding the biology of the Shiga toxins might be instrumental in addressing this issue.
Jonas, Bergan, Anne Berit, Dyve Lingelem, Roger, Simm, Tore, Skotland, Kirsten, Sandvig   +4 more
openaire   +2 more sources

Shiga toxins

Toxicon, 2001
Shiga toxin and Shiga-like toxins belong to the group of protein toxins which have a moiety that binds to the cell surface and another enzymatically active moiety that after entry into the cytosol inhibits protein synthesis enzymatically. The toxins can also cause apoptosis by mechanisms that may be different from the effect on the protein synthesis ...
openaire   +2 more sources

Entry of Shiga Toxin into Cells

Zentralblatt für Bakteriologie, 1993
The effect of Shiga toxin with mutations in the A fragment has been tested on cells in order to get more information about the processing of the A fragment during entry into the cytosol. A mutant with a deletion between the A1 and A2 domain in the A fragment is resistant to cleavage by trypsin and is less toxic than wild type toxin on both Vero and ...
Sandvig, Kirsten, Dubinina, Elena, Garred, Øystein, Prydz, Kristian, Kozlov, Juri V., Hansen, Steen H., van Deurs, Bo   +6 more
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Protection of Monkeys against Shiga Toxin Induced by Shiga Toxin-Liposome Conjugates

International Archives of Allergy and Immunology, 2002
<i>Background:</i> We previously reported that the purified Shiga toxins (Stx) Stx1 and Stx2, when coupled with liposomes, induced substantial production of anti-Stx1 and anti-Stx2 IgG antibody, respectively, in mice. The levels of anti-Stx antibody in the sera of mice immune to Stx-liposome correlated well with the protection against ...
Yuriko, Suzaki, Yasushi, Ami, Noriyo, Nagata, Seishiro, Naito, Hiroshi, Kato, Maiko, Taneichi, Motohide, Takahashi, Takako, Komiya, Sachihiro, Satoh, Fumio, Gondaira, Junichi, Sugiyama, Yoshio, Nakano, Masahito, Mori, Katsutoshi, Komuro, Tetsuya, Uchida   +14 more
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Shiga-toxin-converting bacteriophages

Research in Microbiology, 2001
Shiga toxins (Stx) comprise a family of potent cytotoxins that are involved in severe human disease. Stx are mainly produced by Escherichia coli isolated from human and nonhuman sources, and by Shigella dysenteriae type 1. The genes encoding Stx are thought to be generally encoded in the genome of lambdoid prophages (Stx-converting bacteriophages; Stx ...
openaire   +2 more sources